摘要
目的初步探讨吸烟对精神分裂症患者细胞因子及体液免疫的影响。方法把符合ICD-10关于精神分裂症诊断标准的精神分裂症患者分为吸烟组(均为男性)30例和非吸烟组43例,并以健康对照组比较,对患者组、健康组用酶联免疫吸附法(ELISA)测定血清IL-12、TNF-α水平;用透射比浊法测定IgA、IgM、IgG、C3、C4水平,患者组用阳性与阴性症状量表(PANSS)进行精神症状评定。结果精神分裂症患者的非吸烟组血清IL-12水平比吸烟组高,但未达到统计学上意义,其他的六个指标比较亦无显著差异。健康组非吸烟者的IL-12与IgG水平显著高于吸烟者(P<0.05)。吸烟的健康组与患者组相比,患者组C3、C4血清水平明显降低(P<0.01),IgG明显增高(P<0.01)。从性别比较,健康女性的IgG、IgM血清水平较男性高(P<0.05)。在患者组,女性较男性IgG、TNF-α的浓度明显增高(P<0.05)。结论吸烟、性别是影响精神分裂症患者免疫功能的重要因素之一,吸烟与精神分裂症共同作用于免疫系统,进一步加重其免疫功能紊乱。
Objective To investigate the changes of cytokine and humoral immunity in smoking patients with schizophrenia. Methods Seventy-three patients with schizophrenia meeting ICD-10 were enrolled in the study. They were divided into two groups: smoking group including 30 patients and no smoking group including 43 patients. The levels of IL-12, TNF-αin serum were measured with enzyme linked immunosorbent assay(ELISA) method. The levels of IgA, IgM, IgG, C3, C4 in serum were measured with turbidimetry method, and examined 43 normal control subjects. The positive and negative syndrome scales (PANSS) were used to evaluate the psychotic syndromes.Results The level of IL-12 in serum of no smoking patients with schizophrenia was higher than that of patients in smoking group. But there were no significant difference. There were no significant differences in other six targets. The levels of IL-12, IgG in serum of no smoking patients with schizophrenia were higher than that of patients in smoking group (P<0.05). The levels of C3, C4 in serum of the schizophrenic smoking group were lower significantly than that of health smoking person (P<0.01) and IgG was higher significantly. To compare gender, The levels of IgG, IgM in serum of females was higher than that of males (P<0.05). In patients, The levels of IgG, TNF-αin serum of females was higher than that of males(P<0.05).Conclusions Smoking and gender were the important factors that could influence immunological function of schizophrenia. Smoking and schizophrenia all contribute to immune system and make the dysfunction more seriously.
出处
《神经疾病与精神卫生》
2005年第2期86-88,91,共4页
Journal of Neuroscience and Mental Health
