摘要
目的探讨Thl，Th2，Thl7，调节性T细胞分化及相关细胞因子在类风湿关节炎（RA）发病机制的相关性。方法选取7l例RA患者作为试验对象，并根据DAS28评分，分为高、中、低活动组，采集试验对象及健康对照组（18名）外周血，采用流式细胞术分别检测Thl，Th2，Thl7及调节性T细胞在RA患者不同活动组的百分率。统计学方法采用t检验。结果RA患者外周血Thl[（6．2＋4．5）％]，Thl7[（1．1±0．9）％]，调节性T细胞[（1．8＋1．2）％]所占外周细胞比例与健康对照组比较差异有统计学意义（P〈0．05）；且Thl，Thl7，调节性T细胞比例与DAS28评分有关。结论Thl，Thl7细胞参与疾病的发生、发展；Th2、调节性T细胞可能阻止疾病的进一步发展。
Objective To explore the correlation between Thl, Th2, Thl7, and Treg cells differentiation and related cytokines in patients with rheumatoid arthritis （RA）. Methods Seventy one patients with active RA were enrolled in this study. They were divided into low, moderate and high disease activity groups according to disease activity score （DAS28）. The frequencies of Thl, Th2, Thl7, and Treg cells in the peripheral blood of RA patients group （n=71） and healthy control group （n=18） were determined by flow cytometry. T test was used for statistical analysis. Results Significant difference could be detected between the proportions of Thl [（6.2±4.5）%1, Thl7 [（1.1±0.9）%] and Treg [（1.8±1.2）%] cells in the peripheral blood of RA patients and the control group （P〈0.05）, and there was correlation between proportions of these three kinds of cell and the DAS28. Conclusion Thl and Th 17 cells may promote the development of RA disease, but Th2 and Treg cells could prevent further development of RA disease.
出处
《中华风湿病学杂志》
CAS
CSCD
北大核心
2012年第4期229-232,共4页
Chinese Journal of Rheumatology
基金
山西省自然科学基金（2007011116）
