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胆管癌的基因表达及其临床意义 被引量：3

GENE EXPRESSION IN CHOLANGIOCARCINOMA AND ITS CLINICAL SIGNIFICANCE
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摘要 目的　寻找对胆管癌早期诊断和判断其预后有意义的指标。方法　复习国内外文献有关胆管癌组织中各种基因的改变及其临床意义。结果　胆管癌组织中存在多种基因的点突变、缺失和过度表达 ,其中以K ras基因的研究最为深入。结论　K Objective To search for the significant early diagnostic and prognostic indicators in cholangiocarcinoma. Methods Literatures about the variation of various kinds of genes in cholangiocarcinoma and their clinical significances were reviewed.Results There are several genes mutation, deletion and overexpression in cholangiocarcinoma, K ras gene was most deeply investigated. Conclusion ras mutation detection may be of help in the early finding and prognosis of cholangiocarcinoma.
作者 李哲夫 史光军
机构地区 青岛市市立医院肝胆外科
出处 《中国普外基础与临床杂志》 CAS 2000年第2期131-132,F003,共3页 Chinese Journal of Bases and Clinics In General Surgery
关键词 胆管肿瘤 癌基因 基因表达 Cholangioneoplasm Oncogene Gene expression
分类号 R735.8 [医药卫生—肿瘤]
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参考文献21

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  • 2Kiba T, Tsuda H, Pairojkul C, et al. Mutations of the p53 tumor suppressor gene andthe ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand 〔J〕.Mol Carcinog, 1993; 8(4)∶312
  • 3王征旭,何振平,房殿春,鲁荣,罗元辉,彭志明.胆管癌ras癌基因、p53抑癌基因突变及表达的研究[J].癌症,1997,16(1):48-51. 被引量：6
  • 4Ohashi K, Tsutsumi M, Nakajima Y, et al. High rats of K-ras point mutation in bothintra- and extra-hepatic cholangiocarcinomas 〔J〕. Jpn J Clin Oncol, 1994; 24(6)∶305
  • 5Tsuda H, Satarug S, Hongsa V, et al. Cholangiocarcinoma in Japanese and Thaipatients: difference in etiology and incidence of point mutation of the K-ras pro-oncogene〔J〕. Mol Carcinog, 1992; 6(4)∶266
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  • 7Levi S, Ispizua U, Gill R, et al. A multiple K-ras codon mutations incholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique 〔J〕.Cancer Res, 1991; 51(13)∶3497
  • 8Majima T, Tsujinchi T, Tsutsumi M, et al. Matations of K-ras but not p53 gene inbiliary duct and pancreatic duct carcinoma induced in hamsters by cholocystoduo denostomywith dissection of the common duct followed by N-nitrosobis (2-oxopropyl) amine 〔J〕.Cancer Lett, 1997; 118(1)∶47
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中国普外基础与临床杂志
2000年 第2期

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