摘要
目的 分析健康人群流行性乙型脑炎（乙脑）病毒中和抗体水平特征和影响因素.方法 采用随机抽样方法在信阳市和洛阳市选择＜1岁、1～2岁、3～4岁、5～6岁、7～14岁、15～19岁、20 ～59岁、≥60岁8个年龄组健康人群,分别于2010年5月和11月两次采集血液标本并进行流行病学调查,用微量细胞中和试验检测乙脑病毒中和抗体.结果 两市共调查519人,两次共采集和检测有效血液标本1008份,其中男性乙脑病毒中和抗体阳性率为59.52％,女性为67.39％,男女中和抗体阳性率差异无统计学意义（x2=3.41,P＞0.05）.5月,两市中和抗体阳性率为58.66％,11月为61.20％,乙脑流行前后中和抗体阳性率差异无统计学意义（x2 =0.68,P＞0.05）.信阳市0～14岁中和抗体阳性率为55.19％,洛阳市为45.03％,两市0～14岁中和抗体阳性率差异无统计学意义（x2=3.53,P＞0.05）；信阳市≥15岁中和抗体阳性率为97.78％,洛阳市为48.94％,两市≥15岁中和抗体阳性率差异有统计学意义（x2=55.42,P＜0.05）.两市有乙脑免疫史者中和抗体阳性率为56.85％,无乙脑免疫史者为38.35％,有无免疫史者中和抗体阳性率差异有统计学意义（x2=10.88,P ＜0.05）.结论 信阳市和洛阳市≥15岁人群间、有无乙脑免疫史人群间乙脑病毒中和抗体均有显著性差异,建议信阳市和洛阳市加强0～14岁人群免疫接种,同时关注和探讨洛阳市≥15岁人群免疫策略.
Objective To analyze the prevalence characteristics and influence factors of Japanese encephalitis（JE） neutralizing antibody in healthy people.Methods Xinyang and Luoyang is the two cities in Henan Province.In 2010,healthy people of these two cities were selected by random sampling method to eight age groups：less than one year old,1 - 2 years old,3 - 4,5 - 6,7 - 14,15 - 19,20 - 59,and above 60 years old,their blood specimens were collected in May before JE infection and in November after JE infection,then followed with epidemiological investigation for JE neutralizing antibody by MCPENT.Results 519 healthy people were surveyed,1008 effective blood specimens were collected and tested.The JE neutralizing antibody positive rate was 59.52% in men,and 67.39% in male,these two rates had no statistical significance （x2=3.41,P 〉 0.05 ）.The JE neutralizing antibody was 58.66% in May,and 61.20% in November,these two rates had no statistical significance （x2 =0.68,P 〉 0.05）.The JE neutralizing antibody positive rate of 0 - 14 years old age group was 55.19% in Xinyang,and 45.03% in Luoyang,these two rates had no statistical significance（x2 =3.53,P 〉 0.05 ）.The JE neutralizing antibody positive rate of above 15 years old age group is 97.78% in Xinyang,and 48.94% in Luoyang,these two rates had statistical significance （x2 =55.42,P 〈 0.05）.The JE neutralizing antibody positive rate of JE vaccination was 56.85%,and 38.35 % in no JE vaccination,these two rates had statistical significance（x 2=10.88,P 〈 0.05 ）.Conclusion The JE neutralizing antibody positive rate was showing significant differences in people above 15 years old between Xinyang and Luoyang.The JE neutralizing antibody positive rate was showing significant differences between.JE vaccination and no vaccination.Xinyang and Luoyang City,recommended strengthening the 0 -14 year-olds immunized,and at the same time,exploring and paying attention to JE immunization strategy of people above 15 years old in Luoyang.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2011年第6期401-404,共4页
Chinese Journal of Experimental and Clinical Virology
基金
河南省医学科技攻关项目（项目号：200702016）
关键词
脑炎
日本
抗体
病毒
监测
免疫学
Encephalitis, Japanese
Antibodies, viral
Monitoring,immunologic
