摘要
目的:研究帕金森病(PD)非运动症状(NMS)发生和分布特点及其美多巴治疗后的变化,为早期诊断、病情进展和预后评估及治疗提供依据。方法:对PD组和对照组行NMS问卷调查,给予美多巴治疗3个月,依据统一帕金森病评分量表、简易精神状态检查、汉密尔顿抑郁量表、匹兹堡睡眠质量指数、便秘问题量表评估对照。结果:PD组出现记忆下降、便秘、情绪下降、感觉下降等与对照组相比具有显著差异(P<0.05),而头晕、失眠、泌尿系症状两组间无显著差异(P>0.05)。其中以记忆下降发生率最高,其次为便秘、注意力下降、汗多、流涎;美多巴对改善NMS亦有一定的疗效。结论:(1)NMS存在于PD各期,其中以记忆下降发生率最高;(2)美多巴对改善NMS亦有一定疗效。
Objective,To explore the incidence and its distribution of NMS in PD patients and after treatment,to provide a basis for early diagnosis, progression and prognosis and therapeutic. Methods, An NMS questionnaires survey was performed in PD patients ~and control group. Madopar treatment for 3 months, according to the UPDRS, MMSE, HDRS, PSI ,CPS for assessment of NMS . Resuhs,PD group appeared memory drops, constipation, mood, feeling decline, compared with the normal, group with significant difference （P 〈 0.05 ）, dizziness, insomnia, urinary symptoms, appeared there are no significant differences （ P 〉 0.05 ）; the incidence of memory impairment is the highest, relatively high incidence constipation , attention drops , sweat , salivation;Madopa for treatment of NMS have a certain effect. Conclusion, （1）NMS are more commonly occurred throughout the stages of PD, the incidence of memory impairment is the highest. （2） Madopar on improvement of NMS have a certain effect.
出处
《科技通报》
北大核心
2012年第2期29-31,共3页
Bulletin of Science and Technology
关键词
帕金森病
非运动症状
记忆障碍
parkinson＇s disease
non-motor symptoms
emory impairment
