摘要
不孕不育是一个高度遍及全球的生殖健康问题,近年来不孕症患者呈逐年增长趋势。该病已成为影响人类发展与健康的一个全球性医学和社会学问题。自从1978年世界上首例"试管婴儿"——英国的Louise Brown经体外受精(IVF)而诞生,辅助生殖技术(ART)逐渐成为不孕夫妇的重要治疗手段。ART包括人工授精(AI)、体外受精与胚胎移植(IVF-ET)、胞浆内单精子注射(ICSI)、生殖细胞及胚胎冷冻技术等。而其他ART也在快速改革发展,包括一些建立在辅助生殖与人类基因组之间的桥梁。一系列辅助生殖相关技术,如未成熟卵母细胞体外培养成熟(IVM)、移植前遗传学诊断(PGD)、单胚胎移植以及冷冻技术等获得了较大的发展,为降低常规IVF-ET的费用、风险等提供了可能。综述当前临床及实验性ART技术的相关研究进展。
Infertility is a global reproductive health problem, the number of patients with infertility has increased year by year. Since the first ＂test-tube baby＂ in the world, UK＇s Louise Brown, was born via in vitro fertilization （IVF）in 1978, assisted reproductive technology （ART）has been the leading surgical treatment for couples diagnosed with infertility. ART included artificial insemination （AI）,in vitro fertilization and embryo transfer （IVF-ET）,intracytoplasmic sperm injection （ICSI）,embryo eryopreservation technology and so on. Many other ARTs are been rapidly evoluting, such as some ARTs based on human genomies. A series of new ARTs, such as in vitro oocyte maturation （IVM）, preimplantation genetic diagnos（PGD）, single embryo transfer, gamete and embyo freezing and frost thawing technology, have been developed. These new ARTs provided possibilities to reduce cost and risk of routine in vitro fertilization and embryo transfer（IVF-ET）. In this paper, we reviewed the clinical and experimental progress of ARTs.
出处
《国际生殖健康／计划生育杂志》
CAS
2012年第2期108-114,共7页
Journal of International Reproductive Health/Family Planning
关键词
生殖技术
辅助
受精
体外
胚胎移植
精子注射
细胞质内
植入前诊断
胚胎培养技
术
低温保存
Reproductive techniques,assisted
Fertilization in vitro
Embryo transfer
Sperm injections,intracytoplasmic
Preimplantation diagnosis
Embryo culture techniques
Cryopreservation
