摘要
蛋白质组学主要研究基因编码的所有蛋白质，近年来已成为全面分析蛋白质表达变化的有力手段。蛋白质组学在胃肠肿瘤研究中的应用开始越来越多，通过双向凝胶电泳等各种技术，已经筛选出多种与胃肠肿瘤预后相关的差异蛋白，发现了多种潜在的胃肠肿瘤标志物；在胃肠肿瘤的发生、发展机制方面，通过蛋白质组学发现了多种与肿瘤细胞营养摄取、细胞代谢等影响肿瘤发生的蛋白，发现了多种影响细胞黏附、迁移和细胞骨架重塑的转移相关蛋白；利用蛋白质组学技术还发现了化疗药物和分子靶向治疗耐药的相关机制。蛋白质组学在胃肠肿瘤的基础和临床研究中发挥了越来越重要的作用。
Proteomics is a technology to study all the proteins encoded by gene. It has become a useful tool for analyzing the expression changes of proteins, and has been widely used in research of gastrointestinal tumors in recent years. Through kinds of techniques such as two-dimensional gel electrophoresis, some differentially expressed proteins correlated with patients prognosis were found, which may served as the possible biomarkers of gastrointestinal tumors in future. It helped to find some certain proteins related to tumor cell nutritional intake, cell metabolism, cell adhesion, cell migration and cytoskeleton remodeling which may play the important roles in development of gastrointestinal tumor. It also helped to explain the drug resistance mechacism of chemotherapy and molecular targeted theraphy for gastrointestinal tumors. Proteomics technology plays an increasingly important role in the basic research and clinical services for gastrointestinal tumors.
出处
《国际外科学杂志》
2012年第3期196-199,共4页
International Journal of Surgery
基金
高等学校博士学科点专项科研基金资助项目（No.200800100098）
关键词
蛋白质组学
胃肿瘤
结直肠肿瘤
Proteomics
Gastric neoplasms
Colorectal neoplasms
