摘要
为了解手术对胃肠道恶性肿瘤患者细胞免疫功能和体液免疫功能的影响 ,以 2 1例胃癌、结直肠癌患者作自身对照研究 ,检测手术前后血清中肿瘤坏死因子 - α、可溶性白介素 - 2受体、Ig G、Ig M、Ig A、C3 和 C4的含量。与术前相比 ,患者术后第 1d血清肿瘤坏死因子 - α及可溶性白介素 - 2受体无明显改变 ,术后第 7d均明显减少 (P<0 .0 1) ;术后第 7d血清中 Ig G无明显改变 ,Ig M明显升高 (P<0 .0 1) ,Ig A升高 (P<0 .0 5 ) ,C3 、 C4无明显改变。证实胃肠道恶性肿瘤患者免疫功能低下与肿瘤负荷状态有关 ,切除肿瘤可使患者的细胞免疫功能得到改善 ,也可使体液免疫功能得到部分改善。
The effects of surgery on cellular and humoral immune function in the patients with gastric cancer and colorectal cancer were investigated. Self control study was performed on 21 patients with gastric cancer and colorectal cancer. The changes in serum levels of TNF α, sIL 2R, IgG, IgA, IgM, C 3 and C 4 were determined during the perioperative period. As compared with those before operation, TNF αand sIL 2R had no obvious change at the first postoperative day, but decreased markedly 7 days after operation ( P <0 01). At the 7th postoperative day, IgM and IgA was increased ( P <0.01 and P <0 05 respectively). No remarkable change was observed in IgG, C 3 and C 4 ( P >0 05). It was suggested that the immune deficiency in the patients with gastric cancer and colorectal cancer was closely related with the 'tumor burden state'. Remove of the tumor by surgery would improve the cellular immune function and partly the humoral immune function.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
2001年第4期350-352,共3页
Acta Universitatis Medicinae Tongji
基金
国家自然科学基金资助项目 (No.39970 6 93)
关键词
胃肠肿瘤
外科手术
细胞免疫
体液免疫
gastric cancer
colorectal cancer
surgery
immune, cellular
immune, humoral
