摘要
目的 :研究喉癌癌变过程中 Cyclin E的临床病理学意义。方法 :用免疫组化检测 2 0例正常喉粘膜 ,4 0例喉不典型增生和 6 0例喉癌组织中 Cyclin E的表达。结果 :Cyclin E阳性表达定位于肿瘤细胞核。在喉癌癌变过程中 ,喉正常粘膜、不典型增生病变和喉癌中 Cyclin E阳性表达率分别为 :5.0 % (1/2 0 ) ,2 0 .0 % (8/4 0 )和 4 5.0 % (2 7/6 0 ) (P <0 .0 0 1)。喉癌淋巴结转移组 Cyclin E阳性表达率明显高于非淋巴结转移组。结论 :Cyclin E异常表达可能是喉癌发生中早期分子事件 。
Objective:To investigate the clinicopathlogical nature of the Cyclin E expression in laryngeal carcinogenesis.Methods:The expression of Cyclin E was examined by immunohistochemistry method in 60 cases of laryngeal cancers.Results:The positive expression to Cyclin E was localized in the nuclei of neoplastic cells.In nomal squamous epithelium,dysplastic squamous epithelium and in squamous cell carcinoma of the larynx,the positive immunostaining rate of Cyclin E protein was 5 0%(1/20),20 0%(8/40) and 45 0%(27/60) respectively (P<0 001).Cyclin E expression was observed more frequently in the tumors with lymph node metastasis (P<0 01).Conclusion:These data suggested that expression of Cyclin E could be an early molecular event in the carcinogenesis of larynx and played an important role in the laryngeal carcinoma. [Chinese Arch Otolaryngol Head Neck Surg,2000;7(1):41~43 From the Department of Otalaryngology,Jining First People's Hospital,Shandong Ji ning,272111 (Dr.Wang Jianbo)]
出处
《耳鼻咽喉（头颈外科）》
2000年第1期41-43,共3页
Chinese Arch Otolaryngology-Head Neck Surg
