摘要
目的：考察单味当归，当归与常用中药丹参、冰片配伍以及三药组成复方后的透皮特性。方法：以阿魏酸为指标成分，采用体外透皮吸收实验方法和ＨＰＬＣ检测法。结果：当归所含阿魏酸的渗透系数大于单体阿魏酸（Ｐ＜ ０ ．０１）；当归伍用丹参后其所含阿魏酸的渗透系数减小（Ｐ＜ ０ ．０１）；冰片对当归所含阿魏酸具有促透作用（ Ｐ＜０ ．０１） 。附方中阿魏酸的渗透系数大于单味当归及当归－ 丹参、当归－ 冰片配伍（ Ｐ＜ ０ ．０１）。结论：药材所含某一成分透皮吸收量的变化不仅受配伍药味的影响，药材本身所含成分对其透皮吸收亦有影响；单体、单味中药的透皮情况不能完全反映复方的透皮吸收情况。
Objective: To investigate the characteristics of transdermal absorption of Radix Angelieae Sinensis and its compound formula.Method: Using Valia Chien diffusion cell in vitro,and HPLC to determine the content of ferulic acid(FA).Result: The transdermal permeability coefficient (PC)pf FA,which is the main ingredient of Radix Angelieae Sinensis,is greater than that of the monomer ( P <0.01):the PC of FA is decreased when Radix Angelieae Sinensis and Salviae Miltiorrhizae are used together ( P <0.01):borneol helps enhance the permeation of Radix Angelisas Sinensis ( P <0.01);the PC of the compound formula is greeater than that of the compatibility ( P <0.01).Conclusion: The transdermal absorption of an ingredient of a traditional Chinese drug is affected not by compatibility,but also by other ingredients of the drug.The transdermal absoption of a monomer or a single drug could not fully mirror the absorption of a compound formula.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2000年第1期32-34,共3页
China Journal of Chinese Materia Medica
基金
国家中医药管理局科研基金!(95A3312)
关键词
当归
配伍
复方
透皮吸收
Radix Angelieae Sinensis
compatibility
compound formula
transdermal absorption
