摘要
目的建立银黄注射液生物活性测定法的质量标准。方法用内毒素造成家兔发热模型,观察银黄注射液的解热作用,以采用生物活性测定法评价药品质量。结果静脉注射细菌内毒素可引起家兔稳定的发热,银黄注射液对细菌内毒素所致家兔体温升高有明显抑制作用。结论可以采用药物对细菌内毒素所致家兔发热模型的影响评价银黄注射液的生物活性。
Objective To establish the criteria of bioactivity assay for Yinhuang Injection. Methods The endotoxininduced febrile New Zealand rabbits were chosen as experimental models. The antipyretic effect of Yinhuang Injection was observed and the bioactivity assay was used to estimate the quality of this drug. Results The fever model of rabbits was well established by intravenous injection of endotoxin. Yinhuang Injection had obvious antipyretic effect on the endotoxin-induced febrile rabbits. Conclusion The antipyretic effect of Yinhuang Injection on endotoxininduced febrile rabbits can be used to estimate the quality of this drug as a bioactivity assay.
出处
《食品与药品》
CAS
2012年第2期125-127,共3页
Food and Drug
关键词
银黄注射液
解热
药效学
生物检定
Yinhuang Injection
antipyretic effect
pharmacodynamics
biological assay
