摘要
目的探讨金银花的解热作用及中枢电生理解热机制。方法复制IL-1β性发热新西兰兔模型,观察金银花的解热作用,并应用微电极细胞外放电记录技术观察金银花对IL-1β作用下POAH温度敏感神经元放电频率的影响。结果金银花对IL-1β性发热有解热作用;金银花能增加IL-1β作用下热敏神经元的放电频率,而减少IL-1β作用下冷敏神经元的放电频率。结论逆转IL-1β引起的温度敏感神经元放电频率的改变,可能是金银花起解热作用的机制之一。
Objective To study the antipyretic effect and the mechanism of Jinyinhua （JYH）. Methods Fever models of rabbits were established by intravenous injection of IL - 1β. The antipyretic action of JYH was observed. The firing rates of thermosensitive neurons in the POAH were recorded by extracellular microelectrode technology. Results （1）JYH obviously reduced body temperature of febrile rabbits induced by IL-1β（ P 〈 0.01 ） . （2）After i. v injection of JYH, the firing rates of warm - sensitive neurons responsed to IL - 1β increased from （ 3.2 ±1.6 ） imp/s （ before i. v injection of JYH ） to （9.7 ±4.4 ） imp/s （ P 〈 0.01, n = 13）. In contrast, the firing rates of cold - sensitive neurons decreased from （ 20. 1 ± 5.8 ） imp/s （ before i. v JYH ） to （ 8.4 ±2.0） imp/s （P 〈 0.01, n = 10 ） . Conclusion （DJYH has obvious antipyretic effect on IL-1β-induced fever in rabbits. （2）JYH can reverse the changes of firing rates of thermosensitive neurons treated by IL-1β in POAH and plays an antipyetic effect by increase in heat lost and decrease in heat production.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第9期2071-2073,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家中医药管理局资助项目(No.2003LHR13)
暨南大学病理生理学重点实验室开放基金(No.51207029
51206011)
广东省中医药管理局基金(No.1040074)
