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足细胞病发病机制研究进展 被引量：1

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摘要 足细胞是位于肾小球毛细血管基底膜外侧的脏层上皮细胞。因其胞浆在基底膜表面形成伪足样突起而得名。肾小球滤过屏障至少由5层结构组成：内皮细胞表面膜结构、内皮细胞及内皮细胞窗孔、肾小球基底膜（GBM）、足细胞下间隙和足细胞。这5层结构既独立行使其功能,又相互影响。尽管它们中任何一层功能障碍都会影响到滤过屏障的完整性,但是,足细胞损伤是导致蛋白尿的关键环节。因此,人们将这类由足细胞结构及功能异常引起的肾病综合征称之为足细胞病。
作者 安自民
机构地区 天津市宝坻区人民医院肾内科
出处 《河北联合大学学报（医学版）》 2012年第2期173-174,共2页 Journal of North China Coal Medical College
关键词 足细胞 微小病变 膜性肾病 磷脂酶A2受体 钙神经蛋白
分类号 R692.6 [医药卫生—泌尿科学]
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  • 1潘晓霞,陈楠,周伟,王朝晖,张文,王伟铭,陈晓农,巫永睿,陆颖.原发性局灶节段性肾小球硬化患者CD2AP基因突变的研究[J].中华肾脏病杂志,2006,22(1):13-18. 被引量：24
  • 2师素芳,王素霞,章友康,赵明辉,邹万忠.不同病理类型局灶节段性肾小球硬化症的临床病理分析[J].中华病理学杂志,2007,36(1):11-14. 被引量：5
  • 3Lin CY. Hepatitis B virus deoxyribonucleic acid in kidney cells probably leading to viral pathogenesis among hepatitis B virus associated membranous nephropathy patients. Nephron, 1993,63( 1 ) :58
  • 4Lai KN, Ho RT, Tam JS, et al, Detection of hepatitis B virus DNA and RNA in kidneys of HBV related glomerulonephritis. Kidney Int, 1996,50(6) :1965
  • 5Sung JJ, Chan HL, Wong ML, et al, Relationship of clinical and virological factors with hepatitis activity in hepatitis B e antigen-negative chronic hepatitis B virus-infected patients. J Viral Hepat,2002,9(3):229
  • 6Kaneko S, Feinstone SM, Miller RH. Rapid and sensitive method for the detection of serum hepatitis B virus DNA using the polymerase chain reaction technique. J Clin Microbiol, 1989,27(9): 1930
  • 7H.L. Zaaijer, F. ter Borg, H.T.M. Cuypers, et al. Comparison of methods for detection of hepatitis B virus DNA. Journal of Clinical Microbiology, 1994,32, 2088
  • 8Stoll-Becker S, Repp R, Glebe D, et al, Transcription of hepatitis B virus in peripheral blood mononuclear cells from persistently infected patients. J Virol, 1997,71 (7): 5399
  • 9Combes B, Shorey J, Barrera A, et al, Glomerulonephritis with deposition of Australia antigen-antibody complexes in glomerular basement membrane. Lancet, 1971,31 ;2(7718) :234
  • 10Akano N, Yoshioka K, Aya N, et al, Immunoelectron microscopic localization of membrane attack complex and hepatitis B e antigen in membranous nephropathy. Virchows Arch A Pathol Anat Hiatopathol, 1989,414(4) :325

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  • 1陈娣,肖婧,张林娟,吕永曼,邵菊芳.α3β1整合素在糖尿病大鼠肾脏的表达及其与足细胞减少的关系[J].医学分子生物学杂志,2007,4(4):293-298. 被引量：6
  • 2Zhang A, Huang S. Progress in pathogenesis of proteinuria [ J] . IntJ Nephrol,2012,2012:314251.
  • 3Reiser J, von Gersdorff G, Loos M, et al. Induction of B7 - 1 inpodocyte is associated with nephrotic syndrome[ J] . J Clin Invest,2004,113(10):1390-1397.
  • 4Reiser J,Oh J,Shirato I. Podocyte migration during nephrotic syn-drome requires a coordinated interplay between cathepsin L and al-pha3 integrin[J]. J Biol Chem,2004,279?33) :34827 -34832.
  • 5Kojima K,Davidovits A,Poczewski H,et al. Podocyte flattening anddisorder of glomerular basement membrane are associated with split-ting of dystroglycan - matrix interaction [ J ]. Am Soc Nephrol,2004,15(8):2079 -2089.
  • 6Danapani SV,Sugimoto H,Matthews BD,et al. a - Actinin - 4 isrequired for normal podocyte adhesion[ J]. J Biol Chem,2007,282(1):467 -477.
  • 7Marshall,Sally M.The Podocyte: a potential therapeutic target in dia-betic nephropathy[J]. Curr Pharm Des,2007,13(26) :2713 -2720.
  • 8Tsuji T. Physiological and Pathological Roles of a3pl Integrin[ J].J Membrane Biol, 2004, 200(3) :115 -132.
  • 9Hamerski DA, Santoro SA. Integrin and kidney: biology andpathobiokogy [ J ]. Curr Opin Nephrol Hypertens, 1999,119(Ptl9): 9-14.
  • 10Mizuno H,Ogura M, Saito Y, et al. Changes in adhesive and mi-gratory characteristics of hepatocellular carcinoma ( HCC) cells in-duced by expression of alpha3betal integrin [ J ]. Biochim BiophysActa, 2008, 1780(3) ; 564-570.

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河北联合大学学报（医学版）
2012年 第2期

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