期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

特发性膜性肾病与M型磷脂酶A2受体的研究进展 被引量：3

Research progress of idiopathic membranous nephropathy and phospholipase A2 receptor
原文传递
导出
摘要 人类肾小球足细胞靶抗原——M型磷脂酶A2受体及其自身抗体的发现使得人们对特发性膜性肾病的发病机制有了新的认识，同时为其临床诊治提供了新的思路。本文主要就磷脂酶A2受体结构和生理作用、与特发性膜性肾病发病的关系，以及磷脂酶A2受体及其抗体临床应用前景的研究进展做一综述。 Phospholipase A2 receptor, a transmembrane protein located on glomerular podocytes, had been proved to be the target antigen in idiopathic membranous nephropathy and provided us a new road to uncover the mechanisms of its pathogenesis. In this review, we described the structure and physiological function of phospholipase A： receptor and highlighted the role of its autoantibody in idiopathic membranous nephropathy. Finally we suggested several possible aspects of its future clinical application.
作者 刘琳 陈丽萌 李学旺
机构地区 中国医学科学院北京协和医学院北京协和医院肾内科
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2012年第9期792-794,共3页 Chinese Journal of Laboratory Medicine
基金 国家自然科学基金资助项目（30971369,81170674,30770861）
关键词 肾小球肾炎 膜性 受体 磷脂酶A2 Glomerulonephritis, membranous Receptors, phospholipase A2
分类号 R692.3 [医药卫生—泌尿科学]
  • 相关文献

参考文献25

  • 1Glassock RJ. Diagnosis and natural course of membranous nephropathy. Semin Nephrol, 2003, 23:324-332.
  • 2Cattran D. Management of membranous nephropathy: when and what for treatment. J Am Soc Nephrol, 2005, 16:1188-1194.
  • 3Heymann W, Hackel DB, Harwood S, et al. Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions. Proc Soc Exp Biol Med, 1959, 100:660-664.
  • 4Couser WG, Salant DJ. In situ immune complex formation and glomerular injury. Kidney Int, 1980, 17:1-13.
  • 5Makker SP, Singh AK. Characterization of the antigen ( gp600 ) of Heymann nephritis. Lab Invest, 1984, 50:287-293.
  • 6Debiec H, Guigonis V, Mougenot B, et al. Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N Engl J Med, 2002, 346:2053-2060.
  • 7Beck LH Jr, Bonegio RG, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med, 2009, 361:11-21.
  • 8Hanasaki K. Mammalian phospholipase A2: phospholipase A2 receptor. Biol Pharm Bull, 2004, 27 : 1165-1167.
  • 9Kudo I, Murakami M. Phospholipase A2 enzymes. Prostaglandins Other Lipid Mediat, 2002, 68-69:3-58.
  • 10Liu NK, Xu XM. Phospholipase A2 and its molecular mechanism after spinal cord injury. Mol Neurobiol, 2010, 41 : 197-205.

二级参考文献29

  • 1Kudo I, Murakami M, Phospholipase A2 enzymes[J]. Prostaglandins Other Lipid Medlar, 2002, 68-69: 3-58.
  • 2Gutierrez JM, Ownby CL. Skeletal muscle degeneration induced by venom phospholipases A2 : insights into the mechanisms of local and systemic myotoxicity [J].Toxicon, 2003, 42(8) : 915- 931.
  • 3Zuliani JP, Fernandes CM, Zamuner SR, et al.Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity [J]. Toxicon, 2005, 45(3): 335-346.
  • 4Santamaria C, Larios S, Angulo Y, et al. Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region [J]. Toxicon, 2005, 45(7):807-815.
  • 5Boskovic J, Arnold JN, Stilion R, et al. Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor [J]. J Biol Chem, 2006, 281 (13):8780-8787.
  • 6Nicolas JP, Lambeau G, Lazdunski M. Identification of the binding domain for secretory phospholipases A2 on their M-type 180- kDamembrane receptor [J]. J Biol Chem, 1995, 270 (48): 28869-28873.
  • 7Hanasaki K, Yokota Y, Ishizaki J, et al. Resistance to endotoxic shock in phospholipase A2 receptor-deficient mice [J]. J Biol Chem, 1997, 272(52): 32792-32797.
  • 8Granata F, Petraroli A, Boilard E, et al. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor [J]. J Immunol, 2005, 174(1): 464-474.
  • 9Triggiani M, Granata F, Balestrieri B, et al. Secretory phospholipases A2 activate selective functions in human cosinophils [J]. J Immunol, 2003, 170(6): 3279-3288.
  • 10Jo EJ, Lee HY, Lee YN, et al. Group IB secretory phospholipase A2 stimulates CXC chemokine ligand 8 production via ERK and NF-kappa B in human neutrophils [J]. J Immunol, 2004, 173(10):6433-6439.

共引文献7

同被引文献19

引证文献3

二级引证文献19

中华检验医学杂志
2012年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部