摘要
目的研究p16蛋白表达与新疆哈萨克族食管鳞癌生物学行为的关系。方法应用免疫组织化学SP法检测30例食管鳞癌和60例正常食管组织中p16蛋白的表达。结果 60例正常组织中p16蛋白阳性表达率为88.33%(53/60);30例食管鳞癌组织中p16蛋白表达阳性率为46.67%(14/30)。随着恶性程度增加及病程进展,p16蛋白阳性率逐渐下降,p16在高分化鳞癌组阳性表达率(75%)显著高于低分化鳞癌组(25%)(P<0.05)。结论 p16蛋白表达缺失可能与哈萨克族食管癌的发生发展有关。
Objective To study the relationship between the p16 protein expression and biological behavior of esophageal squamous cell carcinoma in Kazak.Methods Use immunohistochemistry（SP method）to detect 30 cases of esophageal squamous cell carcinoma and 60 cases of p16 protein in normal esophageal mucosa.Results The expression of p16 protein was found positive in 56 cases among 60 cases of normal esophageal mucosa（positive rate 88.33%）.The p16 protein positive rate of 30 patients with esophageal squamous cell carcinoma was 46.67%（14/30）.With the increasing degree of malignancy and disease progression,the positive rate decreased gradually.The positive rate of p16（75%） in well-differentiated squamous cell carcinoma was significantly higher than that of poorly differentiated squamous cell carcinoma（25%）（P0.05）.Conclusion p16 protein expression loss may be related to the occurrence of esophageal squamous cell carcinoma in Kazak.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2012年第3期289-291,共3页
Cancer Research on Prevention and Treatment
基金
国家科技支撑计划资助项目(2009BAI82B00)
