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钙池操纵性钙通道的激活信号分子与肺动脉高压 被引量：4

Pulmonary Artery Hypertension and Signaling Molecules in Activation of Store-Operated Calcium Channels
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摘要 钙池操纵性钙通道是非兴奋细胞上Ca2+内流的主要途径,以钙释放激活钙离子流最为典型。目前发现,由基质交感分子、Orai和经典瞬时感受器电位亚家族等介导的钙池操纵性钙内流参与了多种生理及病理过程。文章通过介绍钙池操纵性钙内流复合体的分子组成及其相互作用模式,以及钙池操纵性钙内流在肺动脉高压发病过程中的作用,旨在为肺动脉高压的防治提供新的研究方向。 Calcium（Ca2＋） entry into non-excitable cells is mainly carried by store-operated calcium channels（SOCC）.The best characterized SOCC current is the Ca2＋ release-activated Ca2＋（ICRAC） current.Recently,store-operated calcium entry（SOCE） mediated by the STIM,Orai and TRPC involved in a variety of physiological and pathological processes.This paper describes the molecular elements of store-operated calcium inux complex（SOCIC）,their interaction,as well as the role of SOCE in the pathogenesis of pulmonary artery hypertension（PAH）,which aimed at providing new research directions about prevention and treatment of PAH.
作者 刘青 林默君
机构地区 福建医科大学生理学与病理生理学系
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2012年第3期273-277,共5页 Chinese Journal of Arteriosclerosis
基金 福建省自然科学基金(C1010116) 福建医科大学重大科研项目资助(09ZD010)
关键词 钙释放激活钙内流 基质交感分子 ORAI 瞬时感受器电位 Store-Operated Calcium Entry Stromal Interaction Molecule Orai Transient Receptor Potential
分类号 R363 [医药卫生—病理学]
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参考文献24

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二级参考文献33

  • 1章新华,陈磊,王怀良,高举.大鼠肺动脉压检测方法学研究[J].中国医科大学学报,2004,33(5):388-389. 被引量：21
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二级引证文献9

中国动脉硬化杂志
2012年 第3期

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