摘要
钙离子（Ca^2＋）是常见的第二信使，不同于其它第二信使，其主要位于细胞外或存储于内质网（endoplasmicreticulum，ER）等细胞器内。静息状态下细胞内游离Ca^2＋浓度（intracellular Ca^2＋ concentra．tion，[Ca^2＋]i）约为细胞外的1／20000，受体激活或生物信号刺激可通过改变[Ca^2＋]i进一步发挥生物放大效应。[Ca^2＋]；
Endoplasmic reticulum calcium （ Ca^2＋ ） sensor stromal interaction molecule 1 （STIM1） and plasma membrane Ca^2＋ channel Orail are the bona fide molecular components of the store-operated Ca^2＋ entry （SOCE） and the Ca^2＋ release-activated Ca^2＋ current （ICRAC）- We have uncovered the protein expression of STIMI and Orail in various tis- sues and described many kinds of roles for these proteins under physiological and pathophysiological conditions. Here, we summarize the novel findings pertaining to the role of STIM1 and Orail in the vascular system and discuss their potential use as targets in the treatment of vascular diseases.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2013年第1期179-182,187,共5页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.31160239)
关键词
钙
钙通道
基质相互作用分子1
Orai1
血管疾病
钙库操纵钙通道
Calcium
Calcium channels
Stromal interaction molecule 1
Orail
Vascular diseases
Store- operated Ca2~ channels
