摘要
目的探讨血清瞬时受体电位通道1(TRPC1)、分泌型卷曲相关蛋白5(sFRP5)、N端前体脑钠肽(NTproBNP)与慢性心力衰竭(chronic heart failure,CHF)患者心功能及疾病严重程度的价值。方法选取2019年6月~2020年6月青海省心脑血管病专科医院收治的217例慢性心力衰竭患者,根据美国纽约心脏病协会(New York heart association,NYHA)心功能分级分为Ⅱ级组74例,Ⅲ级组86例和Ⅳ级组57例,再选取同期健康体检者70例为对照组。比较各组血清TRPC1,sFRP5,NT-proBNP水平、心功能指标,Spearman相关性分析血清TRPC1,sFRP5,NTproBNP水平与心功能分级、心功能指标的关系。结果对照组、Ⅱ级组、Ⅲ级组和Ⅳ级组血清TRPC1(10.61%±2.06%,28.03%±4.51%,42.60%±5.70%,54.09%±6.69%),sFRP5(50.31±7.26,61.91±8.40,70.25±9.66,93.09±12.50ng/L),NT-proBNP(54.26±10.60,380.29±36.01,546.52±44.27,801.36±52.09ng/L)水平呈上升趋势,差异均有统计学意义(F=939.480,225.752,4277.753,均P<0.05),LVEDD(43.06±4.11,48.20±5.30,54.20±6.16,58.02±6.79mm)依次呈上升趋势,LVEF(67.33%±9.79%,60.19%±8.25%,55.12%±7.24%,43.69%±5.37%)依次呈下降趋势,差异均有统计学意义(F=90.491,99.507,P<0.05);TRPC1与心功能分级和LVEDD呈正相关(r=0.966,0.828,均P<0.05),与LVEF呈负相关(r=-0.818,P<0.05);sFRP5与心功能分级和LVEDD呈正相关(r=0.925,0.802,均P<0.05),与LVEF呈负相关(r=-0.787,P<0.05);NT-proBNP与心功能分级和LVEDD呈正相关(r=0.966,0.834,均P<0.05),与LVEF呈负相关(r=-0.796,P<0.05)。结论血清TRPC1,sFRP5和NT-proBNP水平与慢性心力衰竭患者病情严重程度呈正相关,可为临床评估慢性心力衰竭患者病情提供参考。
Objective To investigate the value of serum transient receptor potential channel 1(TRPC1), secreted frizzled-related protein 5(sFRP5) and N-terminal probrain natriuretic peptide(NT-proBNP) in predicting cardiac function and disease severity of chronic heart failure(CHF). Methods A total of 217 patients with chronic heart failure admitted to Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist Hospital from June 2019 to June 2020 were selected. According to NYHA cardiac function classification, they were divided into grade Ⅱ Group(74 cases), grade Ⅲ group(86 cases) and grade IV group(57 cases), and 70 healthy people were selected as control group. The levels of serum TRPC1, Sfrp5, NT proBNP and cardiac function indexes were compared. Spearman correlation analysis was used to analyze the relationship between the levels of serum TRPC1, Sfrp5, NT proBNP and cardiac function grading and cardiac function indexes. Results Serum TRPC1, sFRP5 and NTproBNP levels were 10.61%±2.06%, 50.31±7.26 ng/L and 54.26±10.60 ng/L in control group, 28.03%±4.51%,61.91±8.40 ng/L and 380.29±36.01 ng/L in grade Ⅱ group, were 42.60%±5.70%, 70.25±9.66 ng/L and 546.52±44.27 ng/L in grade Ⅲ group, and were 54.09%±6.69%, 93.09±12.50 ng/L and 801.36±52.09 ng/L in grade Ⅳ group, showing an upward trend(F=939.480, 225.752, 4 277.753, all P<0.05). Meantime, LVEDD of control group, grade Ⅱ group, grade Ⅲ group, and grade Ⅳ group was 43.06±4.11, 48.20±5.30, 54.20±6.16 and 58.02±6.79 mm, showing an upward trend. LVEF of control group, grade Ⅱ group, grade Ⅲ group, and grade Ⅳ group was 67.33%±9.79%, 60.19%±8.25%, 55.12%±7.24% and 43.69%±5.37%, showing a downward trend(F=90.491, 99.507, all P<0.05). TRPC1 was positively correlated with cardiac function classification and LVEDD(r=0.966, 0.828, all P<0.05), and negatively correlated with LVEF(r=-0.818, P<0.05).sFRP5 was positively correlated with cardiac function classification and LVEDD(r=0.925, 0.802, all P<0.05), and negatively correlated with LVEF(r=-0.787, P<0.05). NT-proBNP was positively correlated with cardiac function classification and LVEDD(r=0.966, 0.834, all P<0.05), and was negatively correlated with LVEF(r=-0.796, P<0.05). Conclusion Serum TRPC1, sFRP5 and NTproBNP levels were positively correlated with the severity of patients with chronic heart failure, which can be used as reliable indicators in the clinical evaluation.
作者
王麟
陈惠新
李小燕
WANG Lin;CHEN Hui-xin;LI Xiao-yan(Emergency Center,Qinghai Province Cardiovascular and Cerebrovascular Diseases Specialist Hospital,Xining 810012,China)
出处
《现代检验医学杂志》
CAS
2021年第6期6-9,82,共5页
Journal of Modern Laboratory Medicine
基金
青海省科学技术项目,编号:9632020J0489。
关键词
慢性心力衰竭
瞬时受体电位通道1
分泌型卷曲相关蛋白5
N端前体脑钠肽
chronic heart failure
transient receptor potential channel 1
secreted frizzled-related protein 5
N-terminal probrain natriuretic peptide
