摘要
目的:研究冠状动脉造影(CAG)和经皮冠状动脉介入治疗(PCI)患者对比剂肾病(CIN)的发病率及危险因素。方法:选择2010年10月至2011年4月南京军区南京总医院接受CAG和PCI的患者672例,以术后48h血清肌酐(SCr)较术前升高25%或升高44.2μmol/L(0.5mg/dl)作为CIN的诊断标准,分析CIN的发病率及危险因素。结果:672例患者中,年龄≥65岁者292例(43.5%),冠心病588例(87.5%),高血压461例(68.6%),糖尿病144例(21.4%),术前SCr≥110μmol/L者30例(4.5%),贫血42例(6.3%),服用血管紧张素转换酶抑制剂344例(51.2%),利尿剂95例(14.1%),二甲双胍39例(5.8%),对比剂用量≥200ml者237例(35.3%)。672患者中55例(8.2%)发生CIN,发生CIN者与非CIN者在年龄≥65岁、冠心病、对比剂用量≥200ml及利尿剂等方面有明显差异(P<0.05)。Logistic多因素回归分析显示,年龄≥65岁、对比剂用量≥200mL是CIN的独立危险因素。结论:在CAG和PCI患者的CIN发病率较高,年龄≥65岁和对比剂用量≥200mL是其独立危险因素。
Objective ： To investigate the incidence and the rick factors of contrast-induced nephropathy （CIN） in patients undergoing coronary angiography （CAG） and percutaneous coronary intervention （PCI）. Methodology： From October 2010 to April 2011, a total of six hundred and seventy two cases undergoing CAG and PCI were recruited. CIN is identified if the serum creatinine is increased by 25% or 44. 2 μmol/L （0. 5 mg/dl） of the baseline at 48 hours post procedure. The incidence and the rick factors of CIN were analyzed. Results：Of six hundred and seventy two patients, 292 cases （43.5%） were aged over ≥65 588 （87.5%） had coronary heart disease,461 （68.6%）had hypertension,144 （21.4%） had diabetes mellitus,30 （4. 5% ） had SCr more than 110 μmol/L before procedure,42 （6. 3% ） had anemia, 344 （51.2%） took ACEI,95 （ 14. 1% ） took diuretics,39 （5.8%） took metformins,and 237 cases （35.3%） had the volume of contrast media ≥200 ml. Among the 672 patients,CIN occurred in 55 patients and the incidence of CIN was 8. 2%. There were significant differences between CIN and non-CIN patients in terms of ages over 65, coronary heart disease, the volume of contrast meida ≥200 ml. diuretics （P 〈 0. 05 ）. Logistic regression analysis showed that age ≥65, and the voluem of contrast media ≥200 ml were independent risk factors of CIN. Conclusion：The incidence of CIN in patients undergoing CAG and PCI was higher. The age ≥65 and the volume of contrast meida ≥200 ml were independent risk factors of CIN.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2012年第1期24-28,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
冠状动脉介入术
对比剂肾病
危险因素
percutaneous coronary intervention contrast-induced nephropathy risk factor
