摘要
八乙基卟啉以吡咯为合成前体 ,主要有 2种基本合成路线 ,一是以 5-甲基 -3 ,4 -二乙基 -2 -乙氧羰基吡咯为合成前体 ,由吡咯 α位甲基的碳原子构成卟啉的次甲基桥 ,另一路线是以 3 ,4 -二乙基吡咯为合成前体经与甲醛缩合 ,并以甲醛碳原子构成卟啉的次甲基桥 ,本文详细地介绍了这些中间体和八乙基卟啉的合成 ,并对比较典型的
There are two fundamental synthetic routes for octaethylporphyrin from pyrroles.In the first route,3,4 diethyl 5 methyl 2 ethoxycarbonylpyrrole is used as the precursor and the pyrrolic α methyl carbon turned into the methine bridge of porphyrin.In the second route,the methine bridge composed of the formaldehyde carbon atom was prepared in acid catalysis by condensation of 3,4 diethylpyrrole with formaldhyde.In this paper synthesis of the intermediates and porphyrin are introduced in detail,and six representative total synthetic methods for octaethylporphyrin are reviewed.
出处
《化学试剂》
CAS
CSCD
2000年第1期30-33,共4页
Chemical Reagents
关键词
八乙基卟啉
全合成
吡咯环
合成路线
octaethylporphyrin
3,4 diethylpyrrole
5 methyl 3 ethyl 4 acetyl 2 ethoxycarbonylpyrrol
