摘要
研究了阿霉素、寡霉素和秋水仙素对细胞光电流的影响 ,发现细胞光电流的变化可适时表征药物对细胞的作用 ,且药物对细胞光电流的抑制率具有剂量和时间依赖性 .据此提出了“光激励酶促反应加速模型”。
The effectiveness of doxorubicin, oligomycin and cholchicine on living cells was studied with the photoelectric method in this paper. The results indicated that the change of photoelectric current can reflect the effectiveness of drugs on living cells, and the inhibition effect of drugs on the photoelectric current of living cells was dependent on the drug concentration and drug treating time. Based on these results, a model of “light induced enzymatic reaction acceleration” for the photoelectric behavior of mammalian cells had been proposed as well.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2000年第3期354-357,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金!(批准号 :39730 16 0 )
关键词
哺乳动物
细胞
光电行为
光电流
药物
Mammalian cell
Photoelectric behavior
Photoelectric current
