摘要
Objective ; To study effects of Jiangtang Fanglong Wan （glucose-lowering and deafness-preventing capsule） on hearing in an animal model of diabetes. Methods Wistar rats were used to create a diabetes model by intraperitoneal injection of streptozotocin （STZ, 55 mg/kg）. Forty rats were randomly selected to receive Jiangtang Fanglong Wan （ 10 g/kg/ day） through intragastric garage （treatment group） or normal saline （control group）. Auditory brainstem responses （ABRs） were recorded at Months 1, 2 and 3. Results ABR latencies and wave intervals were similar between the two groups at Month 1 （P 〉 0.05）. ABR latencies and wave intervals were shorter in the treatment group than those of the control group at Months 2 and 3 （P 〈 0.05 and P 〈 0.01, respectively）. Conclusion Our results suggest that Jiangtang Fanglong Wan may have a beneficial effect in preventing and treating hearing impairment associated with diabetes.
Objective ; To study effects of Jiangtang Fanglong Wan （glucose-lowering and deafness-preventing capsule） on hearing in an animal model of diabetes. Methods Wistar rats were used to create a diabetes model by intraperitoneal injection of streptozotocin （STZ, 55 mg/kg）. Forty rats were randomly selected to receive Jiangtang Fanglong Wan （ 10 g/kg/ day） through intragastric garage （treatment group） or normal saline （control group）. Auditory brainstem responses （ABRs） were recorded at Months 1, 2 and 3. Results ABR latencies and wave intervals were similar between the two groups at Month 1 （P 〉 0.05）. ABR latencies and wave intervals were shorter in the treatment group than those of the control group at Months 2 and 3 （P 〈 0.05 and P 〈 0.01, respectively）. Conclusion Our results suggest that Jiangtang Fanglong Wan may have a beneficial effect in preventing and treating hearing impairment associated with diabetes.
