摘要
目的探讨神经肽Ｙ（ＮＰＹ）在血液透析（ＨＤ）中的意义。方法采用放射免疫分析法对３５例ＨＤ患者进行血小板提取液和血浆中ＮＰＹ含量检测，并以３０例健康人作为对照。结果ＨＤ患者血小板中ＮＰＹ含量明显低于对照组，ＨＤ 后增高；血浆中ＮＰＹ水平高于对照组，ＨＤ后降低；提取液中ＮＰＹ水平减少与血浆增高呈显著负相关。结论ＨＤ患者血小板中ＮＰＹ由于病理因素大量释放入血浆，参与了缩血管效应。
Objective To evaluate change and significance of neuropeptide Y (NPY) in platelet of patients during hematodialysis. Methods The NPY contents in platelet and plasma of 35 patients were detected by radioimmunoassay indergoing hematodialysis, and 30 healthy peoples as control. Results The NPY content in patients platelet in the patient were signifcantly lower than that in control and increased after hematodialysis. The NPY contents in plasma were signficantly higher than those in control and decreased after hematodialysis. The decrease of NPY in extract was negatively correlated with the increase of NPY in plasma. Conclusion NPY in patients platelet largely release that into plasma,which may play an important role in pathophysiologg of the patients.
出处
《临床内科杂志》
CAS
2000年第2期111-112,共2页
Journal of Clinical Internal Medicine
关键词
神经肽Y
血小板
血液透析
Neuropeptide Y
Platelet
Hematodialysis
