摘要
用组织化学和免疫组织化学方法检测肝细胞癌(HCC)、肝细胞不典型增生(LCD)和癌旁非LCD的γ-GT酶、甲胎蛋白、癌胚抗原和铁蛋白4种肿瘤标志的表达情况。发现HCC、LCD和癌旁非LCD肝细胞均有不同程度表达。与HCC相比,LCD的肿瘤标志表达更接近于癌旁非LCD肝细胞,但又有所不同,提示LCD是一组增生性病变,有轻有重,性质和程度都不尽相同。轻的,其生物学性质接近于正常肝细胞;重的与癌前病变有某些相似之处。
The expressions of γ-glutamyl transpeptidases(γ-GT),alphafetoprotein(AFP),carcinoembryonic antigen(CEA)and ferritin in 22 areas of liver cell dysplasia(LCD),40 areas of hepatocellular carcinoma(HCC)and 42 areas of paraneoplastic non-dysplastic liver cells were studied with the histochemical and immunohistochemical methods.There were different degrees of expressions of the 4 tumor markers in LCD,HCC and paraneoplastic non-dysplastic liver cells.LCD was functionally more similar to paraneoplastic non-dysplastic liver cells than to HCC.The possible premalignant conditions of LCD were stressed.
基金
国家自然科学基金
关键词
肝细胞增生
生物学性质
肝细胞癌
Liver Cell Dysplasia
γ-glutamyl Transpeptidases
Alpha-fetoprotein
Carcinoembryonic Antigen
