摘要
用组织学和免疫组织化学方法探讨116例肝组织中的肝细胞不典型增生(LCD)发生率和乙型肝炎病毒(HBV)抗原的表达情况。发现肝细胞癌(HCC)伴肝硬化的LCD发生率为21/30(70％);单纯肝硬化为2/10(20％);HCC不伴肝硬化1/12(8.33％);正常对照1/64(1.56％)。试验组52例中46例呈HBsAg阳性,其中24例有LCD(52.17％)。而6例HBsAg阴性肝组织中均未发现LCD(P<0.05)。52例中22例HBcAg呈阳性反应,其中14例有LCD(63.64％);30例HBcAg阴性,10例有LCD(33.33％),前者LCD发生率明显高于后者(P<0.05)。结果还发现,HBsAg和HBcAg阴性肝硬化组织中LCD发生率(65.71％;77.78％)明显高于HBsAg和HBcAg阴性的肝硬化及HBsAg、HBcAg阳性的非肝硬化病例(P<0.01,P<<0.05)。表明LCD的发生与肝硬化和HBV均有关。
The incidence of liver cell dysplasia (LCD) and its relationship to hepatitis B antigens were studied in 116 autopsy and biopsy cases of normal, cirrhotic and cancerous livers with histologic ahd immunohistochemical methods. LCD was found in only one of 64 (1.56％) cases with normal livers, in one of 12 (8.33％) cases with hepatocellular carcinoma (HCC) without cirrhosis, in two of 10 (20％) cases with cirrhosis only, and 21 of 30 (70％) cases with cirrhosis and HCC. HBsAg was observed in 46 of 52 cases of cirrhotic and (or) can-cerous Liver tissues, 24 of which (52. 17％) were associated with LCD, while none was seen in 6 cases of HBsAg negative liver tissues (P<0. 05). HBsAg was also found in LCD cells of nine cases. HBcAg was present in 22/52 cases, 14/22 (63.64％) related to LCD, only 10/30 cases (33.33％) of HBcAg negative liver tissues with LCD. LCD IN the former was significantly higher than the later (P<0. 05). The incidence of LCD in HBsAg and HBcAg positive cirrhosis was higher than HBsAg and HBcAg negative cirrhotic or HBsAg and HBcAg positive noncirrhotic liver tissues. These results suggest that LCD is closely associated with HBv and cirrhosis.
出处
《泰山医学院学报》
CAS
1992年第3期217-220,共4页
Journal of Taishan Medical College
关键词
肝细胞癌
肝硬变
肝细胞增生
HBV
liver cell dysplasia
hepatocellular carcinoma
cirrhosis
HBsAg
HBcAg
