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血浆同型半胱氨酸升高与脑梗死患者颈动脉硬化的关系 被引量：26

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摘要 目的:考察血浆同型半胱氨酸(Hcy)水平升高与脑梗死患者颈动脉硬化的关联性。方法:前瞻性纳入脑梗死患者103例,于入院次日采集空腹静脉血以检测血浆Hcy浓度(循环酶法),出院前进行颈动脉多普勒彩色超声检查,根据影像学特征明确有无颈动脉硬化形成;另选取131例同时期体检者作为健康对照。结果:血浆Hcy值呈偏态分布;脑梗死患者血浆Hcy几何均数为14.29(四分位间距:11.58,16.67)μmol/L,显著高于健康对照人群(8.00μmol/L,四分位间距7.10,9.25)(P<0.001);脑梗死患者中颈动脉硬化发生率高达73.8%,硬化组血浆Hcy水平显著高于非硬化组(16.32vs.13.60,P<0.01)。多元Logistic回归分析显示脑梗死患者血浆Hcy水平与颈动脉硬化呈独立相关(OR1.013,95%CI1.00～1.18,P<0.05)。结论:血浆同型半胱氨酸水平升高是颈动脉硬化的一个独立危险因素,并可能与脑梗死有关,有待干预性临床研究的证实。
作者 马如华 卢星文 闫晓英
机构地区 广东医学院附属深圳市西乡人民医院
出处 《实用医学杂志》 CAS 北大核心 2012年第4期600-602,共3页 The Journal of Practical Medicine
关键词 脑梗死 同型半胱氨酸 颈动脉粥样硬化
分类号 R743.33 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献9

  • 1谈晓牧,刘建国,刘怀翔,高海风,张哲成.高同型半胱氨酸血症与脑梗死复发率关系的随访研究[J].中华神经科杂志,2006,39(9):591-594. 被引量：52
  • 2Saposnik G,Ray J G,Sheridan P,et al.Homocysteine-lowering therapy and stroke risk,severlty,and disability:additional findings from the HOPE 2 trial[J].Stroke,2009,40(4):1365-1372.
  • 3Boushey C J,Beresford S A,Omenn G S,et al.A quantitative assessment of plasma homocysteine as a risk factor for vascular disease.Probable benefits of increasing folio acid intakes[J].JAMA,1995,274(13):1049-1057.
  • 4Wang H,Fan D,Zhang H,et al.Serum level of homocysteine is correlated to carotid artery atherosclerosis in Chinese with ischemic stroke[J].Neurol Res,2006,28(1):25-30.
  • 5Aranz A,Hoyos L,Cantú C.Mild hyperhomoeysteinemia and low folate concentrations as risk factors for cervical artefial dissection[J].Cerebrovasc Dis,2007,24(2-3):210-214.
  • 6Moat S J,Lang D,McDowell I F,et al.Folate-homocyaeine-endothelial function and cardio-vascular disease[J].Nutr Biochem,2004,15:64-79.
  • 7McCully K S.Vascular pathology of homocysteinemia:implications for the pathogenesis of arteriosclerosis[J].Am J Pathol,1969,56(1):111-128.
  • 8Wald D S,Law M,Morris J K.Homocysteine and cardiovascular disease:evidence on causality from a meta-analysis[J].BMJ,2002,325(7374):1202.
  • 9Herrmann W.Significance of hyperhomocysteinemia[J].Clin Lab,2006,52(7-8):367-374.

二级参考文献10

  • 1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33093
  • 2Selhub J,D' Angelo A.Relationship between homocysteine and thrombotic disease.Am J Med Sci,1998,316:129-141.
  • 3Loffredo L,Violi F,Fimognari FL,et al.The association between hyperhomocysteinemia and ischemic stroke in patients with nonvalvular atrial fibrillation.Haematology,2005,90:1205-1211.
  • 4Boysen G,Brander T,Christensen H,et al.Homocysteine and risk of recurrent stroke.Stroke,2003,34:1258-1261.
  • 5Del Ser T,Barba R,Herranz AS,et al.Hyperhomocysteinemia is a risk factor of secondary vascular events in stroke patients.Cerebrovasc Dis,2001,12:91-98.
  • 6Bos MJ,van Goor ML,Koudstaal PJ,et al.Plasma homocysteine is a risk factor for recurrent vascular events in young patients with an ischaemic stroke or TIA.J Neurol,2005,252:332-337.
  • 7Duan J,Murohara J,Ikeda H,et al.Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia.Arterioscler Thromb Vasc Biol,2000,20:2579-2585.
  • 8Demuth K,Atger V,Birderie D,et al.Homocysteine decreases endothelin-1 production by cultured human endothelial cells.Eur J Biochem,1999,263:367 -376.
  • 9El Kossi MM,Zakhary MM.Oxidative stress in the context of acute cerebrovascular stroke.Stroke,2000,31:1889-1892.
  • 10VITATOPS Trial Study Group.The VITATOPS (Vitamins to Prevent Stroke) Trial:rationale and design of an international,large,simple,randomized trial of homocysteine-lowering multivitamin therapy in patients with recent transient ischaemic attack or stroke.Cerebrovasc Dis,2002,13:120-126.

共引文献51

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引证文献26

二级引证文献134

实用医学杂志
2012年 第4期

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