摘要
目的:探讨正常值范围内甲状腺激素对2型糖尿病(T2DM)患者颈部动脉粥样硬化的影响。方法:以颈动脉多普勒超声检查所见狭窄程度将248例T2DM患者分为对照组(无狭窄)92例,轻度狭窄组(狭窄<30%)32例,中度狭窄组(30%≤狭窄<70%)93例,重度狭窄组(≥70%组)31例。分析T2DM患者的颈部动脉超声检查结果与血清甲状腺激素水平及其他影响因素的关系。结果:重度狭窄组的游离三碘甲状腺原氨酸(FT3)、高密度脂蛋白胆固醇(HDL-C)均低于轻、中度狭窄组与对照组,三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、收缩压(SBP)均高于轻、中度狭窄组与对照组,轻、中度狭窄组FT3、HDL-C均低于对照组,差异均有统计学意义(P<0.05或P<0.01)。颈动脉狭窄与FT3、HDL-C呈负相关;FT3、HDL-C升高是颈动脉狭窄的保护因素,年龄、TG升高是颈动脉狭窄的危险因素。结论:正常值范围内偏高的FT3可能对T2DM患者动脉粥样硬化具有保护作用。
Objective： To explore the effect of thyroid hormone on carotid artery atherosclerosis in type 2 diabetes mellitus （T2DM） patients with euthyroidism. Methods： According to results of carotid artery color Doppler ultrasound, 248 T2DM patients were divided into four groups, 92 patients without stenosis （control group）, 32 patients with stenosis〈30% （mild stenosis group）, 93 patients with 30%≤ stenosis〈70% （moderate stenosis group） and 31 patients with stenosis ≥ 70% （severe stenosis group）. Results of Doppler ultrasound and levels of serum thyroid hormone were analyzed in four groups. Results： There were significantly lower values of serum triiodothyronine （FT3） and high-density lipoprotein （HDL-C）in severe stenosis group than those of other three groups. The values of trigalloyl glycerol TG）, total cholesterol TC）, low density lipoprotein-cholesterol （LDL-C） and systolic blood pressure （SBP） were significantly higher in severe stenosis group than those of other three groups. Values of FT3 and HDL-C were significantly lower in mild stenosis group, moderate stenosis group and severe stenosis group than those of control group （1~ 〈 0.01 or P 〈 0.05）. The carotid artery atherosclerosis was negatively correlated with levels of FT3 and HDL-C. The increased levels of FT3 and HDL-C were independent protective factors for the carotid artery. The age and increased TG were independent risk factors involved in the severity of carotid artery atherosclerosis. Conclusion： FT3 within a normal level might be a protection factor for atherosclerosis in patients with T2DM.
出处
《天津医药》
CAS
北大核心
2012年第12期1193-1196,共4页
Tianjin Medical Journal
关键词
糖尿病
2型
颈动脉
动脉粥样硬化
颈动脉狭窄
甲状腺激素类
超声检查
多普勒
彩色
diabetes mellitus, type 2
carotid arteries
atherosclerosis
carotid stenosis
thyroid hormones
ultrasonography, doppler, color
