摘要
利用SP免疫组织化学方法检测了 4 0例不同类型霍奇金病 (HD)RS/H细胞及 13例反应性增生淋巴结(RH)的p4 2 /p4 4MAPK和cyclinD1蛋白的表达。结果显示p4 2 /p4 4MAPK及cyclinD1蛋白在HD之RS/H细胞中均呈过度表达 (阳性率分别为 72 5 %和 70 % ) ,且两者阳性率呈明显的正相关 (P <0 .0 1) ,提示MAPK级联信号转导在HD发生中起重要作用 ,并通过诱导cyclinD1蛋白高表达使RS/H细胞持续增殖及演进。
The expressions of p42/44 mitogen activated protein kinase(p42/p44 MAPK ) and cyclin D1 protein were detected by SP immunohistochemical technique in 40 cases of Hodgkkin's disease(HD) and 13 cases of reactive hyperplasia(RH). The results showed that p42/p44 MAPK and cyclin D1 protein were both overexpressed in RS/H cells of HD(positive rates were 72.5% and 70% respectively), and their positive rates were positively correlated(P<0.01). The data suggest that MAPK cascades signal transduction may play an important role in genesis of HD. MAPK may induce overexpression of cyclin D1 protein and result in persistent proliferation and progression of RS/H cells.
出处
《湖南医科大学学报》
CSCD
2000年第1期6-8,共3页
Bulletin of Hunan Medical University
基金
卫生部资助!(981110)
关键词
何杰金氏病
淋巴瘤
信号转导
癌基因蛋白
lymphoma
Hodgkin's disease
signal transduction *
oncogene protein
immunohistochemistry
