摘要
以葡萄糖为起始原料制得苄基葡萄烯糖,再经Ferrier重排、双羟化反应、选择性磺酰化、羟基保护和在碱性条件下关环反应合成了3-O-乙酰基-4,6-二-O-苄基-1,2-环丙烷葡萄糖。其中5个中间体为新化合物,其结构经1H NMR,13C NMR和HR-MS表征。
3-O-acetyl-4,6-di-O-benzyl-1,2-cyclopropaneacetylated glycose was synthesized by a five-step reaction of Ferrier rearrangement,dihydroxylation,selective sulfonylation,hydroxyl protection and ring formation under basic condition from tri-O-benzyl-D-glucal.Five intermediates of them were new compounds which the structures were characterized by 1H NMR,13C NMR and HR-MS.
出处
《合成化学》
CAS
CSCD
北大核心
2012年第1期40-42,110,共4页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(20972151)
关键词
1
2-环丙烷葡萄糖
苄基葡萄烯糖
葡萄糖
合成
1
2-cyclopropaneacetylated sugar
tri-O-benzyl-D-glucal
glucose
synthesis
