摘要
为筛选中药乙醇提取物制备颗粒剂的最佳崩解剂和制备工艺,采用均匀设计方法,以粒度、外观、粒度分布、崩解度作为观测指标进行综合评分,其分值数据经处理得回归方程,根据方程并结合实践经验确定崩解剂加入量和优化工艺。中药不同浓度乙醇提取物制备颗粒时,以10 % PVP作为粘合剂,羧甲基淀粉钠加入量为57% 时结果最佳。羧甲基淀粉钠用于中药醇提取物制备颗粒剂,崩解度较好。
To screen the best disintegrants and preparation technique of granule from alcohol\|extracts of Chinese medicine herbs,the uniform design and comprehensive evaluation methods were used.Using 10% PVP as blinders,the best condition was that CMS Na was added to 57%(w/w)while preparing the granule from alcohol extracts of different concentration.
出处
《中国实验方剂学杂志》
CAS
2000年第1期10-11,共2页
Chinese Journal of Experimental Traditional Medical Formulae
