摘要
目的观察二甲双胍治疗非酒精性脂肪肝的临床疗效。方法 46例确诊的非酒精性脂肪肝患者,饮食控制的基础上,随机分为两组,治疗组23例给予二甲双胍片治疗,对照组23例给予维生素C片治疗,疗程为6个月,比较治疗前后患者的血清转氨酶水平、血脂水平、空腹血糖(FPG)、空腹血清胰岛素(FInS)、胰岛素抵抗指数(HOMA-IR)及肝脏彩色多普勒B超影像学改变。同时观察治疗过程中出现的不良反应。结果治疗组患者的血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清总胆固醇(TC)、三酰甘油(TG)及低密度脂蛋白(LDL-C)水平明显下降(P<0.05,P<0.01),且胰岛素抵抗指数(HOMA-IR)明显改善(P<0.01),肝脏B超影像学显示有所改善;对照组所有指标无明显改善(P>0.05)。两组患者均未出现明显不良反应。结论二甲双胍可以明显改善胰岛素抵抗,对非酒精性脂肪肝有一定的治疗作用。
Objective To assess the therapeutic effect of mefformin on patients with non-alcoholic fatty liver disease. Methods Forty six patients with non-alcoholic fatty liver disease were randomly divided into two groups and the patients in treatment group were treated with metformin （n=23）, while in control group treated with vitamin C（n=23） for consecutive 6 months, and serum transaminase level （ALT, AST）, triglyceride （TG）, cholesterol （TC, LDL-C and HDL-C）, fasting plasma glucose （FPG）, fasting insulin （FINS）, insulin resistance index（IRI）and B-ultrasonic of liver were detected pre- and post- treatment,respectively. Side-effect was also observed during the experiment. Results After taking metformin,the tevels of serum ALT, AST, TG, TC, LDL-C and HOMA-IR decreased significantly （P〈0.05）, B-ultrasonic examination of liver showed the improvement of fatty liver; while the change wasn＇t obvious in control group （P〉0.05）. and no severe side-effects occurred during the experiment. Conclusion Metformin can reduce the insulin resistance, it is an effective remedy for pa- tients with non-alcoholic fatty liver disease.
出处
《中国现代医生》
2012年第2期50-51,共2页
China Modern Doctor
关键词
二甲双胍
维生素C
非酒精性脂肪肝
胰岛素抵抗
Metformin
Vitamin C
Non-alcoholic fatty liver disease
Insulin resistance
