摘要
目的探讨在麻醉诱导期布托啡诺预处理对减轻静脉注射罗库溴铵引起的注射痛的效果。方法ASA分级Ⅰ-Ⅱ级全身麻醉下行择期手术患者150例，按随机数字表法分为布托啡诺组、芬太尼组和对照组，每组50例，全身麻醉诱导时三组分别静脉注射布托啡诺2m卧芬太尼100μg,0．9％氯化钠2ml，注射完毕后30s以0．5ml／s的速度注射丙泊酚2mg／kg行麻醉诱导，120s后给予1％罗库溴铵0．6mg／kg。观察并记录三组的注射痛发生情况及有无恶心、呕吐、呼吸抑制和呛咳等不良反应。结果芬太尼组和布托啡诺组注射痛发生率[10％（5／50）、8％（4／50）]明显低于对照组[82％（41，50）]（P〈0．01），布托啡诺组和芬太尼组比较差异无统计学意义（P〉0．05）。三组患者均无恶心、呕吐、呼吸抑制和呛咳等不良反应发生。结论2mg布托啡诺预处理可减轻静脉注射罗库溴铵的注射痛，且无呼吸抑制、恶心、呕吐和呛咳等不良反应的发生。
Objective To evaluate the effect of pretreatment with butorphanol to prevent injection pain of rocuronium bromide. Methods One hundred and fifty ASA Ⅰ-Ⅱ grade patients, undergoing elective surgery were divided into 3 groups by random digits table with 50 cases each. Butorphanol group received butorphanol 2 mg, fentanyl group received fentanyl 100 μg,and control group received 0.9% sodium chloride when general anesthesia induced. Anesthesia was induced with propofol 2 mg/kg and the test drug was injected over 30 s, 120 s after the test drug injection, 1% rocuronium bromide 0.6 mg/kg was injected. Nausea, vomiting, apnea and bucking were recorded after drugs injection. Results The rates of rocuronium bromide injection pain in fentanyl group [ 10% （5/50） ] and butorphanol group [ 8% （4/50） ] were significant lower than that in control group [ 82% （41/50） ] （P 〈 0.01 ）. None of the patients discovered nausea, vomiting, apnea and bucking in 3 groups. Conclusion Pretreatment with 2 mg butorphanol reduced the incidence of rocuronium bromide injection pain,furthermore,there is no untoward reaction such as nausea, vomiting, apnea and bucking.
出处
《中国医师进修杂志》
2011年第36期17-19,共3页
Chinese Journal of Postgraduates of Medicine
关键词
布托啡诺
芬太尼
罗库溴铵
注射痛
Butorphanol
Fentanyl
Rocuronium bromide
Injection pain
