摘要
目的研究潍坊市女性人群人乳头瘤病毒(HPV)的感染情况、年龄特征及基因型分布,为HPV感染的防治提供理论依据。方法采用核酸分子导流杂交分型技术对1 358例女性患者进行HPV分型检测,并对感染情况及基因亚型分布进行统计学分析。结果 (1)1 358例女性中HPV阳性424例,阳性率为31.22%,感染者中单一感染365例占86.08%,二重以上感染59例占13.92%。<30岁和大于或等于51岁女性是HPV感染高峰,与其他年龄段比较差异有统计学意义(P<0.05)。(2)424例阳性标本共检出HPV 519株,分为19个亚型。分离率高的前5个基因型是HPV16(16.28%)、HPV58(11.63%)、HPV6(10.08%)、HPV33(9.30%)、HPV52(8.53%)。结论 HPV感染具有一定的地域性,开展HPV基因型的检测对宫颈疾病的防治具有重要意义。
Objective To study the female infection status,age characteristics and genotypes distribution of human papillomavirus（HPV） in Weifang area,and to provide a theoretic basis for therapy and prevention against HPV infection.Methods 1 358 female patients were detected for HPV DNA genotypes by DNA hybridization genotyping technique and performed the statistical analysis on the infection status and genetic subtypes distribution.Results（1） Among 1 358 female patients,424 cases were positive HPV with the positive rate of 31.22%.The rate of single infection with HPV was 86.08%（365/424） and the multiple infections rate was 13.92%（59/424）.Females 30 years old and ≥51 years old were HPV infection peaks,showing significant difference compared with other age groups（P0.05）.（2） 519 strains of HPV were isolated from 424 positive samples,including 19 subtypes.The highest isolation rates of genotypes were in turn HPV16（16.28%）,HPV58（11.63%）,HPV6（10.08%）,HPV33（9.30%） and HPV52（8.53%）.Conclusion HPV infections have certain regional character.Conducting the genotypes detection of HPV has important significance in the prevention and treatment of cervical diseases.
出处
《检验医学与临床》
CAS
2012年第1期7-9,共3页
Laboratory Medicine and Clinic
关键词
人乳头瘤病毒
基因亚型
多重感染
human papillomavirus
genetic subtypes
multiple infections
