摘要
目的运用计算机网络药理学技术对调脾护心方所含化学成分的分子作用机制进行分析。方法运用分子对接和复杂网络分析技术研究治疗调脾护心方所含化学成分和靶标之间的相互作用。结果调脾护心方所含化学成分—靶标相互作用网络属于无尺度网络模型,网络的无尺度特性和网络节点的性质可以较好地阐释各化学成分的药理作用。结论该研究结果可为调脾护心方的后续研究提供有用的线索,促进调脾护心方的分子作用机制研究,该研究策略可为中药复方的系统研究提供参考。
Objective To explore the molecular mechanism of chemical components in Spleen-regulating and Heart-nourishing Formula（SHF） by computer network pharmacological technique.Methods Molecular docking and complicated analytical technique were used to study the pharmacodynamic action of chemical components of SHF on the targets.Results We found that SHF component-target networks were scale-free.The network analysis results showed that scale-free feature of interaction network and nature of network node clearly illuminated the pharmacological action of chemical components in SHF.Conclusion The result provide useful information for further research of SHF,and is expected to be helpful for understanding the molecular mechanism of SHF.The results will supply reference for the systematic research of Chinese herbal compound recipe.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2012年第1期25-29,共5页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金课题(81001658)
广东省自然科学基金课题(9151063201000050)
广东省普通高校重点实验室"中医病机与治法研究实验室"开放基金资助项目(AAF111111A10)
关键词
调脾护心方
分子对接
复杂网络
药理学
Spleen-regulating and Heart-nourishing Formula
Molecular docking
Complex network
Pharmacology
