摘要
代谢组学是近年来新发展起来的一门组学,其主要研究体系有生物体液、生物组织及单个细胞的代谢组,利用一些现代的分析技术,如NMR、LC-MS、GC-MS等,取得整个研究体系的多维数据后,利用模式识别和专家系统技术寻找其中的系统生物学信息。本文从代谢组学的发展,代谢组学的研究范围和研究方法,以及在药物的作用机制和安全性评价,疾病模型,特别是中药研究的应用等方面予以阐述。
Metabonomics is a new '-omics' science developed in recent years. Its major research objects cover bio-fluid, bio-tissue and metabolome of single cell.Modern analytical technologies such as NMR, LC-MS and GC-MS are used to obtain multi-dimensional data for the whole research system, then pattern recognition and expert systems are employed to extract systematic bioinformation. In this review, the development of metabonomics, research field, research methods and applications for mechanism of drug action, drug toxicity screening, clinical safety and disease diagnosis, specifically in traditional Chinese medicines are introduced.
出处
《天津药学》
2005年第2期1-6,共6页
Tianjin Pharmacy
关键词
代谢组学
药物研究开发
作用机制
安全性评价
中药现代研究
疾病诊断
Metabonomics, drug research and development, mechanism of drug action, drug toxicity, traditional Chinese medicine, disease diagnosis
