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Axin蛋白在急性白血病患者外周血中的表达及其意义

Expression and significance of Axin protein in peripheral blood in acute leukemia
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摘要 目的:探讨急性白血病患者外周血中Axin蛋白的表达及其意义。方法:应用酶联免疫法检测41例急性白血病患者外周血及43例正常健康成人外周血中Axin蛋白的表达情况。结果:Axin蛋白的表达水平在急性白血病组(0.309±0.093)明显低于正常健康成人组(0.464±0.126)(P<0.05)。Axin蛋白在急性白血病初治组(0.271±0.097)中表达水平低于经治组(0.341±0.079)(P<0.05)。在急性淋巴细胞白血病组(0.313±0.092)和急性髓细胞白血病组(0.307±0.096)患者外周血中,Axin蛋白表达水平无明显差异(P>0.05)。Axin蛋白低水平表达与急性白血病的发生相关(P<0.05),Axin蛋白的表达水平与急性白血病的预后呈正相关(P<0.05),其与急性白血病的分型无明显关联。结论:Axin蛋白的表达水平可为急性白血病的诊断及预后提供有价值的指标。 Objective：To study the expression of Axin protein in the peripheral blood in acute leukemia and its clinical significance. Methods：Enzyme--linked immunosorbent assay was used to detect Axin protein expres- sion in the peripheral blood of 41 cases of acute leukemia and 43 normal healthy adults. Results： The Axin pro- tein expression in acute leukemia group （0. 309±0. 093） was significantly lower than that in the normal healthy adult group （0. 464±0. 126） （P 〈 0.05）. The Axin protein expression in acute leukemia untreated group （0. 271±0. 097） was lower than that in the treated group（0. 341±0. 079） （P 〈 0.05）. In acute lymphoblastic leukemia group （0. 313± 0. 092） and acute mycloid leukemia group （0. 307 ± 0. 096）, Axin protein level showed no significant difference in the peripheral blood in acute leukemia （P 〉0. 05）. Conclusion： The Axin protein expression level may provide valuable theoretical basis in the diagnosis and prognosis of acute leukemia.
作者 于广晴 徐玥玥 李慧 王为光
机构地区 佳木斯大学附属第一医院血液科
出处 《黑龙江医药科学》 2011年第6期19-20,共2页 Heilongjiang Medicine and Pharmacy
关键词 Axin蛋白 急性白血病ELISA 外周血 Axin protein acute leukemia ELISA peripheral blood
分类号 R733.7 [医药卫生—肿瘤]
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参考文献12

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二级参考文献29

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黑龙江医药科学
2011年 第6期

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