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Axin基因与肿瘤相关性的研究进展 被引量：3

Progress of correlativity between Axin and tumors
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摘要 Axin是一个多结构域支架蛋白,对Wnt,JNK等信号途径起重要的调控作用,并且还参与了p53的活化。Axin的异常表达不仅可以导致胚胎体轴复制、胚胎死亡、细胞极性异常,而且与多种肿瘤的发生、发展有密切的关系。将Axin用于肿瘤的基因治疗,已取得了一定的进展,为肿瘤的治疗带来了新的希望。 Axin, a multi-domain scaffold protein, plays an important role in Wnt and JNK signal pathway and p53 activation. The abnormal expression of Axin not only leads to duplication of embryonic axis, embryonic lethality and abnormality of cellular polarity, but also has a close relation with tumorigenesis. The progress of Axin made in gene therapy for tumors will contribute to the therapeutics of tumors.
作者 董承伟 丁怡 曾勇
机构地区 潍坊市人民医院肝胆外科 潍坊医学院病理生理教研室 四川大学华西医院普外二科
出处 《国际病理科学与临床杂志》 CAS 2007年第1期36-39,共4页 Journal of International Pathology and Clinical Medicine
关键词 AXIN 肿瘤 基因治疗 Axin tumor gene theraov
分类号 R730.2 [医药卫生—肿瘤]
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参考文献29

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共引文献2

同被引文献35

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引证文献3

二级引证文献8

国际病理科学与临床杂志
2007年 第1期

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