摘要
目的:检测血清半胱氨酸蛋白酶抑制剂C(胱抑素C,Cys-C)浓度,评价其对糖尿病肾病患者的早期诊断价值。方法:应用乳胶颗粒增强散射免疫比浊法(PENIA)测定88例糖尿病患者和30名健康体检者的血清Cys-C浓度,并同时测定血清肌酐(SCr)、β2-微球蛋白(β2-MG)、糖化血红蛋白A1(cHbA1c)、尿微量白蛋白(UMA)和尿肌酐(UCr),计算出内生肌酐清除率(CCr)。比较Cys-C与其他指标的相关性。结果:微量白蛋白尿组和临床白蛋白尿组的Cys-C、SCr、CCr、β2-MG、UMA均较正常白蛋白尿组和健康对照组有显著性差异;Pearson相关分析显示:糖尿病患者血Cys-C与SCr、β2-MG、UMA呈正相关,与CCr呈负相关。结论:Cys-C在评价糖尿病患者的肾功能状况时与SCr的相关性好且灵敏度高于Ccr、UMA和β2-MG等肾小球滤过率标志物。故Cys-C对糖尿病肾病早期诊断价值较其他指标更高。
Objective： To test the concentration of cystatin C （Cys-C）and evaluate the value in diagnosis of early diabetic nephropathy. Methods： The levels of serum Cys-C in 88 cases of diabetes and 30 healthy comparisons were determined by particle enhanced nephelometric immunoassay （PENIA）. On the same time, SCr, β2-MG, UMA, glyeosylated hemoglobinAlc （HbA1c） and urine creatinine（UCr） were measured in all patients. The Ccr was calculated ,and Cys-C was compared with other indicators as well as the area under the ROC curve. Results： The levels of all of indicators in microalbuminuria group and clinical proteinuria group were much higher than those in normal proteinuria and healthy subjects;Cys-C and SCr, β2-MG , UMA were positively correlated, Cys-C and CCr were negative correlation. Conclusion： Cys-C and UMA have a good correlation and the sensitivity of Cys-C is higher than that of Ccr, SCr, β2-MG and other markers of glomerular filtration rate in the evaluation of renal function in patients with diabetes mellitus. The value of Cys-C for the diagnosis of diabetic nephropathy is higher than that of other indicators.
出处
《天津医科大学学报》
2011年第4期536-538,共3页
Journal of Tianjin Medical University
关键词
胱抑素C
Β2-微球蛋白
血清肌酐
内生肌酐清除率
糖尿病肾病
24
h尿微量白蛋白
Cystatin C
β2-microglobulin
Serum creatinine
Endogenous creatinine clearance rate
Diabetic nephropathy
24-hour urinary microprotein albumin
