摘要
目的:分析血清胱抑素C(Cys-C)、尿微量白蛋白/肌酐比值(mAlb/Cr)联合检测在糖尿病患者早期肾损伤的诊断中的应用。方法:选取60例糖尿病患者(研究组)与60例健康体检者(对照组),分别使用免疫透射比浊法、散射比浊法、苦味酸动力学法测定两组的Cys-C、尿微量白蛋白、肌酐水平。结果:研究组Cys-C、mAlb/Cr值分别是(1.43±0.43)mg/L、(12.57±8.13)mg/mmol,均明显高于对照组(P<0.05);研究组Cys-C水平>1.4 mg/L者16例,阳性率为26.7%,mAlb/Cr水平>3 mg/mmol者19例,阳性率为31.7%;两项指标联合检测结果高于正常范围共22例,联合检测阳性率为36.7%,高于两项指标单独检测(P<0.05);本组实际肾损伤22例,联合检测准确率100%。结论:Cys-C、mAlb/Cr比值联合检测可明显提升糖尿病早期肾损伤诊断准确度与敏感度。
Objective：To analyze serum cystatin C（Cys-C）,urinary albumin/creatinine ratio（mAlb/Cr）joint detection in the diagnosis of early diabetic kidney injury. Method：60 cases of diabetic（study group）and 60 healthy volunteers（control group）,respectively used nephelometry,turbidimetry scattering,picric acid groups of the kinetic method measured immune serum cystatin C ,urinary albumin and creatinine levels. Result：The study group’s cystatin C, urine albumin/creatinine ratio averages were（1.43 ± 0.43）mg/L,（12.57 ± 8.13）mg/mmol,were significantly higher （P〈0.05）. The study group’s cystatin C levels〉1.4 mg/L were 16 cases,cystatin C-positive rate of 26.7%;levels of urinary albumin creatinine ratio 〉3 mg/mmol patients with 19 cases ,urinary albumin-creatinine ratio was 31.7%tested positive. Two indicators combined test results above the normal range were 22 cases,the positive rate of combined detection was 36.7%,was higher than positive rate detected separately in two indicators（P〈0.05）. The patients had 22 cases of actual kidney injury,joint detection accuracy rate was 100%. Conclusion：Serum cystatin,urinary albumin/creatinine ratio combined detection of early kidney damage can significantly improve the accuracy and sensitivity of diagnosis of diabetes.
出处
《中国医学创新》
CAS
2014年第8期82-84,共3页
Medical Innovation of China
关键词
血清胱抑素C
尿微量白蛋白
肌酐比值
糖尿病早期肾损害
Serum cystatin C
Urinary albumin / creatinine ratio
Early renal damage in diabetes mellitus
