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前列腺增生和癌变组织中c-met蛋白表达的意义 被引量：4

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摘要 目的 :探讨肝细胞生长因子受体 (c-met)蛋白在前列腺增生 (BPH)和前列腺癌 (PC)中表达及其与细胞增殖和血管形成之间的关系。方法 :应用免疫组化SP方法检测 18例正常前列腺 (NP)、6 2例BPH和 33例PC组织中c -met蛋白的表达及其PCNA指数和微血管密度 (MVD)。结果 :PC组织中c -met表达显著高于BPH和NP上皮细胞中表达 ,后两者之间比较也有显著性差异。但两者间质组织中表达无显著差异。BPH上皮细胞和PC组织中c-met表达与PCNA指数正相关 ,但与MVD之间均无显著相关性。c -met表达与肿瘤病理分化分期之间密切相关。结论 :c -met可能通过促进细胞增殖增加的途径而在前列腺上皮细胞增生和癌变的发生发展过程中起重要作用 。
作者 谢庆祥 汪鸿 缪友仁 李金雨
机构地区 解放军第
出处 《中国现代医学杂志》 CAS CSCD 2000年第1期26-27,共2页 China Journal of Modern Medicine
基金 南京军区联勤部十八分部科研基金资助! ( 98010501)
关键词 前列腺增生 前列腺肿瘤 C-MET蛋白 血管形成
分类号 R737.250.2 [医药卫生—肿瘤]
  • 相关文献

参考文献8

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二级参考文献10

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共引文献2

同被引文献22

  • 1王共先,胡峰,曹润福,习海波,傅斌,胡红林,熊礼生.后腹腔镜肾蒂淋巴管结扎术治疗乳糜尿(附29例报告)[J].临床泌尿外科杂志,2004,19(11):665-667. 被引量：12
  • 2陆曙炎,陈建国,张焕兴,周忠兴,邹建钢,吴小鹏,陈仰之,陈静,刘伟民,高谷深.后腹腔镜手术治疗泌尿系疾病(附23例报告)[J].中华泌尿外科杂志,1997,18(2):110-112. 被引量：113
  • 3姚华强,刘春晓,谢庆祥.血小板衍生生长因子受体在前列腺良恶性病变中的表达及意义[J].中华泌尿外科杂志,1997,18(1):24-26. 被引量：5
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  • 6Ghoussoub RAD;Dillon DA;D'Aquila T.Expression of c-met is a strong independent prognostic factor in breast carcinoma[J],1998.
  • 7Taniguchi K;Yonemura Y;Nojima N.The relation between the growth patterns of gastric carcinoma and the expression of hepatocyte growth factor receptor (c-met) autocrine motility factor receptor and urokinase-type plasminogen activator receptor[J],1998(82).
  • 8Montesano R;Matsumoto K;Nakamura T.Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor[J],1991.
  • 9Birchmeier W;Brinkmann V;Niemann C.Role of HGF/SF and c-met in morphogenesis and metastasis of epithelial cells,1997.
  • 10Rosen EM;Joseph A;Jin L.Urinary and tissue levels of scatter factor in transitional cell carcinoma of bladder[J],1997(1).

引证文献4

二级引证文献24

中国现代医学杂志
2000年 第1期

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