摘要
为了探讨碱性成纤维细胞生长因子（ｂＦＧＦ）在前列腺组织中表达、分布情况及临床意义，应用免疫组化方法检测１４例正常前列腺（ＮＰ）、５６例前列腺增生症（ＢＰＨ）和３３例前列腺癌（Ｐｃａ）组织中ｂＦＧＦ的分布和表达。结果显示：ＢＰＨ中ｂＦＧＦ阳性率为６４３％，主要分布于间质细胞核，部分间质细胞浆、少数腺上皮细胞浆也见阳性染色；Ｐｃａ中ｂＦＧＦ阳性表达位于癌细胞浆，阳性率为８４８％，但ｂＦＧＦ表达强度与Ｐｃａ的病理分级、临床分期无明显关系；正常前列腺组织中ｂＦＧＦ表达均为阴性，三者之间阳性率差异有显著意义，表明ｂＦＧＦ参与ＢＰＨ、Ｐｃａ发生过程。
The distribution and expression of basic fibroblast growth factor (bFGF) were instigated by means of immunohistochemical technique in 14 normal prostate (NP),56 benign prostatic hyperplasia (BPH) and 33 prostatic carcinoma (Pca).36 of the BPH were positively stained,located predominantly in the nucli of stromal cells,some being seen in the cytoplasm of stromal cells. 28 of 33 Pca showed positive staining in the cytoplasm of cancer cells. There was,however,no correlation between bFGF expression and tumor grade and stage. All the 14 NP showed negative staining.The difference of bFGF expression among Pca,BPH and NP was significant denoting that bFGF might play an important role in the pathogenesis of BPH and Pca.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1997年第2期107-109,共3页
Chinese Journal of Urology
