摘要
目的:观察丹栀逍遥散合二至丸加减对乳腺癌患者三苯氧胺(TAM)内分泌治疗不良反应的治疗作用。方法:将64例符合入选标准的乳腺癌患者,随机分为治疗组和对照组。治疗组:TAM,每次10 mg,每日2次,温开水送服,同时配合丹栀逍遥散合二至丸加减浓煎300 mL,日1剂,早、晚各服1次。对照组:TAM,每次10 mg,每日2次,温开水送服。治疗2月后评价疗效,比较两组患者库坡曼(kuppermann)症状积分、药物不良反应等观察指标。结果:治疗组kuppermann症状积分明显低于治疗前(P<0.05),临床缓解率(显效+有效)达90.63%;对照组积分较前无改善。两组缓解率比较,差异有统计学意义(P<0.01)。结论:应用TAM配合丹栀逍遥散合二至丸加减治疗乳腺癌,能够改善潮热汗出、失眠、疲乏及情绪异常等内分泌治疗后不良反应,提高生活质量。
Objective：To observe the therapeutical effect of Dan Zhi Xiao Yao San with Er Zhi Wan Jia Jian on adverse reactions of breast cancer of endocrine therapy on tamoxifen（TAM）.Methods：64 patients with breast cancer according to the criteria,randomly divided into the treatment group and control group.The treatment group：TAM,every time 10 mg,2 times a day with lukewarm water service,at the same time cooperating with 300ml fried Dan Zhi Xiao Yao San with Er Zhi Wan Jia Jian,day 1 agent,the morning and evening take 1 times.Control group：TAM,every time 10 mg,2 times a day with lukewarm water service.Evaluate the efficacy after 2 months.Compared the kuppermann symptom scores,adverse drug reaction and other outcome of two groups of patients.Results：The kuppermann symptom scores of treatment group is significantly lower than no treatment（P0.05）,clinical response rate（powerfully＋effective） 90.63%;the control group did not improve the previous points.The remission rate of two groups was significant difference（P0.01）.Conclusion：The application of TAM with Dan Zhi Xiao Yao San with Er Zhi Wan Jia Jian to treat breast cancer,can improve the endocrine therapy adverse reaction such as hot flashes sweating,insomnia,fatigue,and mood disorders.So that we can improve the quality of life.
出处
《中医学报》
CAS
2012年第1期6-8,共3页
Acta Chinese Medicine
基金
国家中医药管理局科技攻关项目(编号:0203JP25)
关键词
丹栀逍遥散
二至丸
乳腺癌
内分泌
更年期综合征
不良反应
Dan Zhi Xiao Yao San
Er Zhi Wan
breast cancer
endocrine therapy
menopause syndrome
adverse reaction
