摘要
目的:探讨以高能聚焦超声热疗(HIFU)为主综合治疗不能手术切除晚期胰腺癌的近期疗效。方法:采用FEP-BY01型高能聚焦超声肿瘤治疗机联合介入或全身化疗、胆总管造口术(合并黄疸者)等措施,对23例不能手术切除的晚期胰腺癌患者进行综合治疗。结果:(1)疼痛改变:23例患者治疗前均有不同程度疼痛,治疗后完全缓解13例(56·5%),部分缓解8例(37·8%),无效2例(8·7%),与治疗前比较差异显著(P<0·01);(2)生活质量(KPS评分):治疗前平均(56·62±13·05)分,治疗后(85·20±5·20)分(P<0·01);(3)近期生存情况:本组病例HIFU治疗后至首次随访时,生存21例,2例分别因合并广泛肝转移和大量腹水全身衰竭死亡;(4)肿瘤体积变化:23例患者肿瘤完全消失1例,部分消失2例,肿瘤体积变化<1/4处于稳定状态17例,病情进展1例,死亡2例。结论:以超声聚焦热疗为主联合化疗及胆总管造口术等综合措施治疗不能手术切除的晚期胰腺癌,可以缓解疼痛,改善生活质量,其近期有效率高,值得进一步研究。
Objective ：To evaluate the combined treatment of unresectable pancreatic carcinoma mainly by high intensity focused ultrasound（HIFU）. Methods： A total of 23 cases of unresectable pancreatic carcinoma were treated by HIFU combined with chemotherapy and cholangiojejunostomy in jaundice patients. Results： （1） Of the 23 cases pain was relieved in 13 cases （ complete response） ,partial response in 8 cases,no response in two cases. The result had a significant difference（ P〈0. 01 ） ; （2） Quality of life （ KPS score） ： the KPS score was （ 56. 62±13.05 ） before treatment, and （ 85.20±5.20 ） after treatment （ P〈0. 01 ） ; （ 3 ） Survival span：all the cases were followed up after treatment. 21 cases were still alive and two cases had died of liver metastasis and as cites; （4） Of the 23 cases,there was one case complete response in the volume of tumor,2 cases partial response, 17 cases no change, one case progress disease and 2 cases died, Conclusion ：The treatment of unresectable pancreatic cancinoma by HIFU, combined with chemotherapy and cholangiojejunostomy, can relieve cancer pain, improve the quality of life. It has a high recent effeetive rate and is worth of further study.
出处
《临床肿瘤学杂志》
CAS
2005年第6期590-592,共3页
Chinese Clinical Oncology
关键词
胰腺肿瘤
高能聚焦超声
药物治疗
胆总管造口术
Pancreatic carcinoma
High intensity focused ultrasound
Drug therapy
Cholangiojejunostomy
