摘要
目的：探讨血清ＩＬ－８ 变化在淋巴系统恶性血液病（ＬＭＨＤ）中的意义。方法：采用夹心酶联免疫吸附法检测３１ 例ＬＭＨＤ患者血清中ＩＬ－８ 水平。结果：急性淋巴细胞白血病（ＡＬＬ）与恶性淋巴瘤（ＭＬ）患者治疗前ＩＬ－８ 水平显著高于正常对照组；非霍奇金淋巴瘤（ＮＨＬ）患者ＩＬ－８ 水平高于霍奇金病（ＨＤ）患者；ＬＭＨＤ患者治疗有效者ＩＬ－８ 水平显著下降，无效者仍保持高水平，完全缓解时与正常对照组无差异。治疗前ＩＬ－８ 水平在无反应者显著高于有反应者。结论：ＩＬ－８ 水平的变化可作为ＬＭＨＤ的病情及监测治疗反应的一种手段。
Objective:To study the clinical significance of serum interleukin 8 levels in patients with lymphatic malignant hematologic diseases(LMHD).Method:Serum level of interleukin 8 was measured in 31 patients with LMHD by sandwich enzyme linked immunosorbent assay(ELISA).Result:The level of IL 8 increased significantly (P< 0.05 ) in acute lymphocytic leukemia (ALL) and lymphoma patients than in normal controls,and the IL 8 level increased significantly (P< 0.05 ) in NHL patients than in HD patients,the IL 8 level declined in responding patients after therapy and there were no differences between CR cases and controls. The IL 8 level before therapy was significantly higher in non responding patients than in responding patients.Conclusion:The changes of IL 8 may serve as a means to observe the condition of LMHD patients and supervise their response to treatment.
出处
《临床血液学杂志》
2000年第1期3-4,共2页
Journal of Clinical Hematology
