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大肠癌患者血清IL-8和MMP-3水平的临床研究 被引量:4

Clinical study on serum interleukin-8 and MMP-3 levels in patients with colorectal carcinoma
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摘要 目的探讨大肠癌患者血清IL-8和MM P-3表达水平及其临床意义。方法应用EL ISA方法,对56例大肠癌患者和同期30名健康人的血清IL-8和MM P-3水平进行测定。结果大肠癌患者血清IL-8和MM P-3水平明显高于正常人,IL-8和MM P-3水平与肿瘤大小、血管侵犯、淋巴结受累、肝脏转移及临床病理分期密切相关(P<0.05),但与肿瘤部位、组织学类型及患者的性别和年龄等因素无关(P>0.05)。大肠癌患者血清IL-8和MM P-3水平表达有显著相关性(P<0.05)。结论IL-8和MM P-3在大肠癌的发生、发展中具有重要作用,术前检测IL-8和MM P-3可作为大肠癌辅助诊断和病情监测的参考指标。
出处 《实用肿瘤杂志》 CAS 2006年第3期237-239,共3页 Journal of Practical Oncology
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  • 1Themsche CV,Potworowski EF,Pierre ST,et al.Stromelysin-1(MMP-3) is inducible in T lymphoma cells and accelerates the growth of lymphoid tumors in vivo[J].Biochem Biophys Res Commun,2004,315(4):884-891.
  • 2Zucker S,Vacirca J.Role of matrix metalloproteinases(MMPs)in colorectal cancer[J].Metastasis Rev,2004,23(1-2):101-117.
  • 3Nawrocki R,Gilles C,Polette M,et al.E-cadherin mediates MMP downregulation in highly invasive bronchial tumor cells[J].Am J Pathol,2003,163(2):653-661.
  • 4Monvoisin A,Bisson C,Tayeb K,et al.Involvement of matrix metalloproteinase type-3 in hepatocyte growth factor-induced invasion of human hepatocellular carcinoma cells[J].Int J Cancer,2002,97(2):157-162.
  • 5Mercapide J,Lopez D,Castresana JS,et al.Tromelysin-1/matrix metalloproteinase-3(MMP-3)expression accounts for invasive properties of human astrocytoma cell lines[J].Int J Cancer,2003,106(5):676-682.
  • 6Hanahan D,Folkman J.Patterns and emerging mechanism of the angiogenic switch during tumorigenesis[J].Cell,1996,86(3):353-364.
  • 7Inoue K,Slaton JW,Kim SJ,et al.Interleukin 8 expression regulates tumorigenicity and metastasis in human bladder cancer[J].Cancer Res,2000,60(8):2290-2299.
  • 8Ren Y,Cecilia L.Interleukin-8 serum levels in patients with hepatocellular carcinoma correlations with clinicopathological features and prognosis[J].Clin Cancer Res,2003,12(7):5996-6001.
  • 9Kitadai Y,Onogawa S,Kuwai T,et al.Angiogenic switch occurs during the precancerous stage of human esophageal squamous cell carcinoma[J].Oncol Rep,2004,11(1):315-319.
  • 10Abdollahi T,Robertson NM,Abdollahi A,et al.Identification of interleukin 8 as an inhibitor of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in the ovarian carcinoma cell line OVCAR3[J].Cancer Res,2003,63(15):4521-4526.

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