摘要
目的探讨白介素-8(IL-8)在恶性肿瘤患者化疗前后血清中表达的临床意义。方法采用酶联免疫吸附法(ELISA)分别检测25例恶性肿瘤患者化疗前后血清IL-8水平,10名正常健康志愿者血清作为对照。结果恶性肿瘤组化疗前血清IL-8含量明显高于对照组(P<0.01),与TNM分期有关,但与肿瘤组织分化类型无明显相关性。化疗后血清IL-8显著下降(P<0.01)。结论IL-8是肿瘤发展和转移的有效生物学指标。化疗后IL-8的表达量可能有助于临床判断化疗近期疗效。
Objective To investigate the clinical significance of the express of serum interleukin-8 before and after chemotherapy in patients with malignant tumor. Methods The serum IL-8 was measured in 25 patients with malignant tumor before and after chemotherapy. Meanwhile, 10 healthy volunteers were involved in the control. Results IL-8 serum levels before chemotherapy were found to be significantly higher in cancer patients than that in the controls （P 〈 0.01 ）. Moreover, they were significantly increased in stage Ⅳ patients compared with that in the stage Ⅱ and stage Ⅲ patients, but there is no relationship with differentiation. IL-8 serum level was decreased significantly after chemotherapy （P 〈 0.01）. Conclusion IL-8 is a useful biological mark in finding out recurrence and metastasis. The level of IL-8 after chemotherapy may reflect the therapeutic effect.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2005年第4期633-634,652,共3页
Suzhou University Journal of Medical Science
