摘要
目的探讨药源性致死的特点和规律,提出临床合理用药的建议,以减少药源性致死病例的发生率。方法检索2005～2010年中国期刊全文数据库CNKI收录的药源性致死个案,利用Excel软件录入相关数据并对其进行汇总性统计和分析。结果药源性致死病例中,60岁以上老年人发病率最高,占29.95%;静脉给药与口服给药为主要的给药方式;引起死亡的药物种类前三位是抗微生物药、中枢神经系统药、中草药,分别占31.31%、18.18%和7.07%;主要致死原因为过敏性休克,占40.40%;20.20%死亡病例属超剂量用药。结论严格掌握用药指征,按照药品说明书的用量用法使用,密切观察用药后反应,同时提高基层人员素质,普及基本医药常识,以减少药源性疾病或药源性致死的发生。
Objective To reduce the incidence of case of drug-induced death by discussing the characteristics and regularity of drug-induced deaths and putting forward recommendations of clinical medication.Methods Do searching cases of drug-induced death published on CNKI from 2005 to 2010,and using excel software to input the data and make Summary of Statistics.Results The old men over 60 age have a higher prevalence,accounting for 29.95% in the cases.The main mode of administration are intravenous and oral administration.The top three types of drugs causing death is anti-microbial drugs,central nervous system drugs,Chinese herbal medicine,accounting for 31.31 %,18.18% and 7.07% respectively.The main cause is anaphylactic shock,accounting for 40.40%.20.20% deaths are due to drug overdose.Conclusion It is necessary to master medication indications strictly,use drugs according to the amount of drugs usage instructions,and observe drug reaction closely,while improving the quality of grassroots staff,spread medical knowledge as well,to reduce cases of drug-induced diseases or drug-induced death.
出处
《中国热带医学》
CAS
2011年第11期1416-1418,共3页
China Tropical Medicine
关键词
药源性致死
合理用药
药品不良反应
Drug-induced death
Rational use of drug
Adverse drug reaction
