摘要
1例39岁女性甲癣患者,联用酮康唑与灰黄霉素治疗2个月余,停药2个月后患者出现皮肤巩膜重度黄染,肝功能试验显示ALT564U/L,AST621U/L,TBil387.0μmol/L,B超检查示肝脏回声增强,腹腔少量积液,诊断为亚急性重症肝炎。入院后虽经保肝、对症治疗及血浆置换,患者肝损害继续加重,出院后死亡。
A 39-year-old woman with onychomycosis took ketoconazole combined with griseofulvin for more than 2 months. Two months after discontinuation of the drugs, she developed severe yellowish in the skin and sclera. Liver function tests showed the following levels： ALT 564 U/L, AST 621 U/L,TBil 387 μmol/L. An ultrasound B examination revealed an increased liver echo intensity and a small amount of hydrops in abdominal cavity. She was diagnosed with severe subacute hepatitis. After admission, despite receiving liver-protective and symptomatic therapy as well as plasmapheresis, her liver damage progressively worsened. She died after discharge.
出处
《药物不良反应杂志》
2008年第2期147-148,共2页
Adverse Drug Reactions Journal
关键词
酮康唑
灰黄霉素
亚急性肝炎
ketoeonazole
griseofulvin
subaeute hepatitis
