摘要
通过使用氢氧化钠的甲醇溶液调节阿奇霉素盐溶液pH值从阿奇霉素盐溶液中直接析晶获得阿奇霉素晶体。实验结果表明:氢氧化钠甲醇溶液浓度0.3mol/L,反应温度30℃,甲醇与水体积比1:1.5析晶结果较好,收率高于萃取浓缩工艺。
Crystallization of azithromycin was obtained directly from aqueous phase by adjusting the pH value with sodium hydroxide which dissolved in methanol. The best conditions were： concentration of sodium hydroxide 0.3 mol/L, temperature 30℃, volumetric proportions of methanol to aqueous 1 ：l. 5. Parallel experiments showed the yield was higher than originally method by extraction and inspissation.
出处
《山东化工》
CAS
2011年第11期21-23,共3页
Shandong Chemical Industry
关键词
阿奇霉素
结晶
中和
azithromy＇cin
crystallization
neutralization
