摘要
目的总结中国2010年度临床痰标本来源细菌的耐药性。方法常规方法培养分离痰标本中的细菌,采用纸片法、MIC法或E-test法测定细菌对抗菌药物的敏感性,使用WHONET5.6对药物敏感性进行分析。结果 2010年度痰标本来源分离出细菌116 646株,前3位菌种为铜绿假单胞菌、鲍氏不动杆菌及肺炎克雷伯菌,分别占17.6%、17.1%及15.4%;青霉素不敏感的肺炎链球菌检出率为23.7%,耐甲氧西林金黄色葡萄球菌(MRSA)和凝固酶阴性葡萄球菌(MRCNS)的检出率分别为71.4%、92.5%;肺炎链球菌和葡萄球菌属对大环内酯类抗菌药物的耐药率>70.0%;嗜血菌属对β-内酰胺类、大环内酯类和喹诺酮类的耐药率为15.0%～20.0%;肠杆菌科细菌对碳青霉烯类耐药率为3.0%～10.0%,铜绿假单胞菌和鲍氏不动杆菌对亚胺培南的耐药率为27.6%和53.4%。结论铜绿假单胞菌、鲍氏不动杆菌和肺炎克雷伯菌为2010年度痰标本来源分离的前3位菌种;痰标本中肺炎链球菌和革兰阴性菌耐药率较高。
OBJECTIVE To summarize the resistance of bacteria isolated from sputum in China in Z010. METHODS The bacteria isoiated form sputum were cultured by routine method, disc diffusion test, MIC test and E-test were used to determine the antimicrobial sensitivity of bacterial isolates, WHONET5.6 software was applied to analyze the bacterial sensitivity. RESULTS A total of 116 646 strains were isolated from sputum samples in 2010, the top 3 pathogens were Pseudomonas aeruginosa , Acinetobacter baumannii and Klebsiella pneumoniae , accounting for 17.6 %, 17.1% and 15.45 %, respectively. The detection rate of penicillin non-susceptible Streptococcus pneumo- nia was 23. 7%. The detection rates of methicillin-resistant S. aureus （MRSA） and coagulase-negative Staphylococcus （MRCNS） were 71. 4% and 92. 5%, respectively. The resistance rates of S. pneumoniae and Staphylococcus to maerolides antibiotics were over 70.0%; The resistance rates of Haemophilus spp to i3-1actams antibiotics, macrolides and fluoroquinolones varied between 15. 0% and 20. 0%. The resistance rates of enterobacteriaceae to carbapenems were 3.0~/700--10.0%. The resistant rates of P. aeruginosa and A. baurnannii to imipenem were 27.6~ and 53.4V00, respectively. CONCLUSION P. aeruginosa, A. baumannii and Klebsiella pneumoniae are the top three species isolated from sputum in 2010. The resistance rates of S. pneumoniae and gram-negative bacteria isolated from sputum are higher.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第24期5157-5161,共5页
Chinese Journal of Nosocomiology
